PSACC_00335 protein (Paramicrosporidium saccamoebae)

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second shell of interactors

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Coexpression

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[Homology]

Score

PSACC_00335

NUC153 domain-containing protein. (173 aa)

Predicted Functional Partners:

PSACC_02391

0.999

PSACC_01486

0.998

PSACC_00917

0.998

PSACC_03664

0.997

PSACC_02930

0.997

PSACC_01017

0.997

PSACC_01594

0.996

PSACC_01201

0.996

PSACC_03362

0.994

PSACC_02252

0.992

Your Current Organism:

Paramicrosporidium saccamoebae

NCBI taxonomy Id: 1246581
Other names: KSL3, P. saccamoebae, Paramicrosporidium saccamoebae Corsaro et al., 2014, fungal sp. KSL3

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PSACC_00335	PSACC_00917	A0A2H9TQ22	A0A2H9TNE8	NUC153 domain-containing protein.	U3 small nucleolar RNA-associated protein 22.	0.998
PSACC_00335	PSACC_01017	A0A2H9TQ22	A0A2H9TN63	NUC153 domain-containing protein.	TRAUB-domain-containing protein.	0.997
PSACC_00335	PSACC_01201	A0A2H9TQ22	A0A2H9TMI8	NUC153 domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.996
PSACC_00335	PSACC_01486	A0A2H9TQ22	A0A2H9TLT8	NUC153 domain-containing protein.	NAT10.	0.998
PSACC_00335	PSACC_01594	A0A2H9TQ22	A0A2H9TLJ7	NUC153 domain-containing protein.	Hemolysin-III-like protein.	0.996
PSACC_00335	PSACC_02252	A0A2H9TQ22	A0A2H9TJL9	NUC153 domain-containing protein.	Uncharacterized protein.	0.992
PSACC_00335	PSACC_02391	A0A2H9TQ22	A0A2H9TJ49	NUC153 domain-containing protein.	Bms1-type G domain-containing protein.	0.999
PSACC_00335	PSACC_02930	A0A2H9TQ22	A0A2H9THQ4	NUC153 domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.997
PSACC_00335	PSACC_03362	A0A2H9TQ22	A0A2H9TGC7	NUC153 domain-containing protein.	Utp6p.	0.994
PSACC_00335	PSACC_03664	A0A2H9TQ22	A0A2H9TFB7	NUC153 domain-containing protein.	KRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.	0.997
PSACC_00917	PSACC_00335	A0A2H9TNE8	A0A2H9TQ22	U3 small nucleolar RNA-associated protein 22.	NUC153 domain-containing protein.	0.998
PSACC_00917	PSACC_01017	A0A2H9TNE8	A0A2H9TN63	U3 small nucleolar RNA-associated protein 22.	TRAUB-domain-containing protein.	0.993
PSACC_00917	PSACC_01201	A0A2H9TNE8	A0A2H9TMI8	U3 small nucleolar RNA-associated protein 22.	WD_REPEATS_REGION domain-containing protein.	0.999
PSACC_00917	PSACC_01486	A0A2H9TNE8	A0A2H9TLT8	U3 small nucleolar RNA-associated protein 22.	NAT10.	0.997
PSACC_00917	PSACC_01594	A0A2H9TNE8	A0A2H9TLJ7	U3 small nucleolar RNA-associated protein 22.	Hemolysin-III-like protein.	0.997
PSACC_00917	PSACC_02252	A0A2H9TNE8	A0A2H9TJL9	U3 small nucleolar RNA-associated protein 22.	Uncharacterized protein.	0.998
PSACC_00917	PSACC_02391	A0A2H9TNE8	A0A2H9TJ49	U3 small nucleolar RNA-associated protein 22.	Bms1-type G domain-containing protein.	0.998
PSACC_00917	PSACC_02930	A0A2H9TNE8	A0A2H9THQ4	U3 small nucleolar RNA-associated protein 22.	WD_REPEATS_REGION domain-containing protein.	0.999
PSACC_00917	PSACC_03362	A0A2H9TNE8	A0A2H9TGC7	U3 small nucleolar RNA-associated protein 22.	Utp6p.	0.998
PSACC_00917	PSACC_03664	A0A2H9TNE8	A0A2H9TFB7	U3 small nucleolar RNA-associated protein 22.	KRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.	0.997

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Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.704

expected number of edges:

16

PPI enrichment p-value:

0.0317

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016311

Dephosphorylation

3 of 21

1.89

1.01

0.0111

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004721

Phosphoprotein phosphatase activity

3 of 20

1.91

1.15

0.0056

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4096

Mixed, incl. Toll Like Receptor 5 (TLR5) Cascade, and Response to host

5 of 12

2.36

3.68

5.25e-08

CL:4098

Response to host, and Toll Like Receptor 5 (TLR5) Cascade

2 of 5

2.34

0.87

0.0259

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-975871

MyD88 cascade initiated on plasma membrane

3 of 6

2.44

2.6

1.17e-05

MAP-168176

Toll Like Receptor 5 (TLR5) Cascade

3 of 6

2.44

2.6

1.17e-05

MAP-168142

Toll Like Receptor 10 (TLR10) Cascade

3 of 6

2.44

2.6

1.17e-05

MAP-181438

Toll Like Receptor 2 (TLR2) Cascade

3 of 8

2.31

2.55

1.17e-05

MAP-168898

Toll-like Receptor Cascades

3 of 8

2.31

2.55

1.17e-05

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13350

Tyrosine phosphatase family

2 of 2

2.74

1.05

0.0125

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR026893

Tyrosine/serine-protein phosphatase IphP-type

3 of 3

2.74

2.09

0.00015

IPR016130

Protein-tyrosine phosphatase, active site

3 of 4

2.61

2.07

0.00015

IPR029021

Protein-tyrosine phosphatase-like

3 of 8

2.31

1.79

0.00042

IPR000387

Tyrosine-specific protein phosphatases domain

2 of 3

2.56

1.04

0.0129

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