STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fbiCFO synthase; COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes. (835 aa)    
Predicted Functional Partners:
AFR_19710
Regulator of sigma subunit, anti-anti-sigma factor RsbU; COG2202 FOG: PAS/PAC domain.
  
    0.913
AFR_05650
LPPG:FO 2-phospho-L-lactate transferase.
 
   
 0.883
AFR_36025
Stage II sporulation protein E; COG2202 FOG: PAS/PAC domain.
   
  
 0.842
AFR_07650
Putative magnesium/manganese-dependent protein phosphatase with GAF domain; COG2202 FOG: PAS/PAC domain.
  
 
 0.840
AFR_01225
Putative magnesium/manganese-dependent protein phosphatase; COG2172 Anti-sigma regulatory factor (Ser/Thr protein kinase).
   
    0.830
AFR_01290
Putative magnesium/manganese-dependent protein phosphatase; COG2208 Serine phosphatase RsbU, regulator of sigma subunit.
   
    0.830
AFR_31380
Putative magnesium/manganese-dependent protein phosphatase with GAF domain; COG2202 FOG: PAS/PAC domain.
   
    0.830
thiG
Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
  
 
 0.809
AFR_05645
Gamma-glutamyl ligase.
 
   
 0.802
AFR_21765
COG0642 Signal transduction histidine kinase.
  
 
 0.772
Your Current Organism:
Actinoplanes friuliensis
NCBI taxonomy Id: 1246995
Other names: A. friuliensis DSM 7358, Actinoplanes friuliensis DSM 7358, Actinoplanes friuliensis HAG 010964
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