STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SIT49222.1NUDIX hydrolase (fragment). (64 aa)    
Predicted Functional Partners:
gcvP
Glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
    
  0.750
nadE-2
Putative glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
    
 0.732
nrdA
Ribonucleoside diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
    
  0.703
SIT43756.1
Conserved membrane hypothetical protein; Homologs of previously reported genes of unknown function.
    
 0.598
nadC
Quinolinate phosphoribosyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the NadC/ModD family.
    
 0.595
SIT42718.1
2-amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinase.
    
 0.593
folC
Bifunctional folylpolyglutamate synthase and dihydrofolate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family.
    
 0.584
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
    
 0.578
fumA
FUMARATE HYDRATASE PROTEIN; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
    
  0.568
dcd
DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE PROTEIN; Catalyzes the deamination of dCTP to dUTP.
    
  0.526
Your Current Organism:
Paraburkholderia ribeironis
NCBI taxonomy Id: 1247936
Other names: Burkholderia sp. STM 7168, Burkholderia sp. STM 7217, Burkholderia sp. STM 7296, DSM 101188, LMG 29351, LMG:29351, P. ribeironis, Paraburkholderia ribeironis Bournaud et al. 2017, STM 7296, STM:7296
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