D779_0526 protein (Imhoffiella purpurea) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

D779_0526

Hypothetical protein. (394 aa)

Predicted Functional Partners:

D779_0525

0.953

D779_0618

0.901

D779_1961

0.874

D779_0524

0.818

tolB

0.776

D779_2889

0.776

D779_4200

0.776

D779_2604

0.775

D779_1039

0.686

D779_2763

0.686

Your Current Organism:

Imhoffiella purpurea

NCBI taxonomy Id: 1249627
Other names: I. purpurea, Imhoffiella purpurea Nupur et al. 2017, JCM 18851, KCTC 15575, MTCC 12304, Thiorhodococcus sp. AK35, strain AK35

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
D779_0524	D779_0525	D779_0524	D779_0525	Diguanylate cyclase.	Hypothetical protein.	0.806
D779_0524	D779_0526	D779_0524	D779_0526	Diguanylate cyclase.	Hypothetical protein.	0.818
D779_0524	D779_2889	D779_0524	D779_2889	Diguanylate cyclase.	Hypothetical protein.	0.403
D779_0524	D779_4200	D779_0524	D779_4200	Diguanylate cyclase.	Hypothetical protein.	0.403
D779_0524	tolB	D779_0524	D779_1779	Diguanylate cyclase.	tolB protein precursor; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.	0.403
D779_0525	D779_0524	D779_0525	D779_0524	Hypothetical protein.	Diguanylate cyclase.	0.806
D779_0525	D779_0526	D779_0525	D779_0526	Hypothetical protein.	Hypothetical protein.	0.953
D779_0525	D779_0618	D779_0525	D779_0618	Hypothetical protein.	Putative TonB-dependent receptor protein.	0.509
D779_0526	D779_0524	D779_0526	D779_0524	Hypothetical protein.	Diguanylate cyclase.	0.818
D779_0526	D779_0525	D779_0526	D779_0525	Hypothetical protein.	Hypothetical protein.	0.953
D779_0526	D779_0618	D779_0526	D779_0618	Hypothetical protein.	Putative TonB-dependent receptor protein.	0.901
D779_0526	D779_1039	D779_0526	D779_1039	Hypothetical protein.	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid.	0.686
D779_0526	D779_1961	D779_0526	D779_1961	Hypothetical protein.	Surface lipoprotein.	0.874
D779_0526	D779_2604	D779_0526	D779_2604	Hypothetical protein.	TonB-dependent receptor.	0.775
D779_0526	D779_2763	D779_0526	D779_2763	Hypothetical protein.	Outer membrane vitamin B12 receptor BtuB.	0.686
D779_0526	D779_2889	D779_0526	D779_2889	Hypothetical protein.	Hypothetical protein.	0.776
D779_0526	D779_4200	D779_0526	D779_4200	Hypothetical protein.	Hypothetical protein.	0.776
D779_0526	tolB	D779_0526	D779_1779	Hypothetical protein.	tolB protein precursor; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.	0.776
D779_0618	D779_0525	D779_0618	D779_0525	Putative TonB-dependent receptor protein.	Hypothetical protein.	0.509
D779_0618	D779_0526	D779_0618	D779_0526	Putative TonB-dependent receptor protein.	Hypothetical protein.	0.901

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

22

average node degree:

4

avg. local clustering coefficient:

0.933

expected number of edges:

17

PPI enrichment p-value:

0.157

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0022900

Electron transport chain

8 of 58

1.98

4.42

1.20e-11

GO:0006120

Mitochondrial electron transport, NADH to ubiquinone

4 of 8

2.53

3.21

8.10e-07

GO:0019646

Aerobic electron transport chain

5 of 30

2.06

2.89

8.10e-07

GO:0042775

Mitochondrial ATP synthesis coupled electron transport

5 of 31

2.04

2.88

8.10e-07

GO:0032981

Mitochondrial respiratory chain complex I assembly

3 of 16

2.11

1.65

0.00062

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008137

NADH dehydrogenase (ubiquinone) activity

7 of 20

2.38

5.8

7.60e-13

GO:0015453

Oxidoreduction-driven active transmembrane transporter activity

8 of 35

2.19

5.66

1.31e-13

GO:0009055

Electron transfer activity

8 of 56

1.99

4.8

7.95e-13

GO:0051539

4 iron, 4 sulfur cluster binding

3 of 38

1.73

1.25

0.0025

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005747

Mitochondrial respiratory chain complex I

9 of 19

2.51

8.72

2.85e-19

GO:1902495

Transmembrane transporter complex

10 of 33

2.32

8.15

1.05e-19

GO:0005746

Mitochondrial respirasome

10 of 39

2.24

7.75

1.79e-19

GO:0098803

Respiratory chain complex

10 of 40

2.23

7.7

1.79e-19

GO:1990204

Oxidoreductase complex

10 of 54

2.1

6.86

9.19e-19

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6225

NADH dehydrogenase complex

9 of 15

2.61

9.05

2.43e-19

CL:6213

NADH dehydrogenase complex, and NADH dehydrogenase (quinone) activity

10 of 34

2.3

7.97

2.43e-19

CL:6227

NADH dehydrogenase complex

6 of 8

2.71

6.47

3.04e-13

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

10 of 114

1.78

4.57

1.64e-15

map01100

Metabolic pathways

11 of 1992

0.58

0.51

3.43e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6799198

Complex I biogenesis

9 of 31

2.3

7.24

3.15e-17

MAP-611105

Respiratory electron transport

10 of 61

2.05

6.23

2.82e-17

MAP-163200

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

10 of 72

1.98

5.84

4.35e-17

MAP-1428517

The citric acid (TCA) cycle and respiratory electron transport

10 of 134

1.71

4.11

1.16e-14

MAP-1430728

Metabolism

10 of 1389

0.69

0.61

7.85e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070469

Respirasome

6 of 51

1.91

3.11

6.05e-08

GOCC:0005743

Mitochondrial inner membrane

6 of 154

1.43

1.73

9.59e-06

GOCC:0005746

Mitochondrial respirasome

3 of 22

1.97

1.65

0.00049

GOCC:0031966

Mitochondrial membrane

7 of 234

1.31

1.61

4.37e-06

GOCC:0098803

Respiratory chain complex

3 of 25

1.91

1.58

0.00064

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0830

Ubiquinone

7 of 33

2.16

5.02

5.25e-12

KW-0679

Respiratory chain

2 of 4

2.53

1.35

0.0034

KW-1278

Translocase

2 of 18

1.88

0.92

0.0172

KW-0813

Transport

4 of 202

1.13

0.75

0.0100

KW-0999

Mitochondrion inner membrane

2 of 33

1.62

0.68

0.0445

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (24%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About