AHM61612.1 protein (Flammeovirgaceae bacterium 311)

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Known Interactions

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Predicted Interactions

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Score

AHM61612.1

Putative two-component sensor histidine kinase transcriptional regulator; COG2972 Predicted signal transduction protein with a C-terminal ATPase domain. (357 aa)

Predicted Functional Partners:

AHM61611.1

0.956

AHM58760.1

0.817

AHM60094.1

0.817

AHM61559.1

0.817

AHM62892.1

0.815

AHM58809.1

0.812

AHM60717.1

0.812

AHM62054.1

0.812

AHM63268.1

0.812

AHM62939.1

0.811

Your Current Organism:

Flammeovirgaceae bacterium 311

NCBI taxonomy Id: 1257021
Other names: F. bacterium 311

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHM58760.1	AHM61612.1	D770_02455	D770_16790	Two-component system-response regulator; COG3279 Response regulator of the LytR/AlgR family.	Putative two-component sensor histidine kinase transcriptional regulator; COG2972 Predicted signal transduction protein with a C-terminal ATPase domain.	0.817
AHM58809.1	AHM61612.1	D770_02700	D770_16790	LytTR family two component transcriptional regulator; COG3279 Response regulator of the LytR/AlgR family.	Putative two-component sensor histidine kinase transcriptional regulator; COG2972 Predicted signal transduction protein with a C-terminal ATPase domain.	0.812
AHM60094.1	AHM61612.1	D770_09185	D770_16790	Two component transcriptional regulator, lyttr family protein; COG3279 Response regulator of the LytR/AlgR family.	Putative two-component sensor histidine kinase transcriptional regulator; COG2972 Predicted signal transduction protein with a C-terminal ATPase domain.	0.817
AHM60717.1	AHM61612.1	D770_12300	D770_16790	LytTR family two component transcriptional regulator; COG3279 Response regulator of the LytR/AlgR family.	Putative two-component sensor histidine kinase transcriptional regulator; COG2972 Predicted signal transduction protein with a C-terminal ATPase domain.	0.812
AHM61559.1	AHM61612.1	D770_16525	D770_16790	LytTR family two component transcriptional regulator; COG3279 Response regulator of the LytR/AlgR family.	Putative two-component sensor histidine kinase transcriptional regulator; COG2972 Predicted signal transduction protein with a C-terminal ATPase domain.	0.817
AHM61611.1	AHM61612.1	D770_16785	D770_16790	COG3279 Response regulator of the LytR/AlgR family.	Putative two-component sensor histidine kinase transcriptional regulator; COG2972 Predicted signal transduction protein with a C-terminal ATPase domain.	0.956
AHM61612.1	AHM58760.1	D770_16790	D770_02455	Putative two-component sensor histidine kinase transcriptional regulator; COG2972 Predicted signal transduction protein with a C-terminal ATPase domain.	Two-component system-response regulator; COG3279 Response regulator of the LytR/AlgR family.	0.817
AHM61612.1	AHM58809.1	D770_16790	D770_02700	Putative two-component sensor histidine kinase transcriptional regulator; COG2972 Predicted signal transduction protein with a C-terminal ATPase domain.	LytTR family two component transcriptional regulator; COG3279 Response regulator of the LytR/AlgR family.	0.812
AHM61612.1	AHM60094.1	D770_16790	D770_09185	Putative two-component sensor histidine kinase transcriptional regulator; COG2972 Predicted signal transduction protein with a C-terminal ATPase domain.	Two component transcriptional regulator, lyttr family protein; COG3279 Response regulator of the LytR/AlgR family.	0.817
AHM61612.1	AHM60717.1	D770_16790	D770_12300	Putative two-component sensor histidine kinase transcriptional regulator; COG2972 Predicted signal transduction protein with a C-terminal ATPase domain.	LytTR family two component transcriptional regulator; COG3279 Response regulator of the LytR/AlgR family.	0.812
AHM61612.1	AHM61559.1	D770_16790	D770_16525	Putative two-component sensor histidine kinase transcriptional regulator; COG2972 Predicted signal transduction protein with a C-terminal ATPase domain.	LytTR family two component transcriptional regulator; COG3279 Response regulator of the LytR/AlgR family.	0.817
AHM61612.1	AHM61611.1	D770_16790	D770_16785	Putative two-component sensor histidine kinase transcriptional regulator; COG2972 Predicted signal transduction protein with a C-terminal ATPase domain.	COG3279 Response regulator of the LytR/AlgR family.	0.956
AHM61612.1	AHM62054.1	D770_16790	D770_19015	Putative two-component sensor histidine kinase transcriptional regulator; COG2972 Predicted signal transduction protein with a C-terminal ATPase domain.	COG3279 Response regulator of the LytR/AlgR family.	0.812
AHM61612.1	AHM62892.1	D770_16790	D770_23235	Putative two-component sensor histidine kinase transcriptional regulator; COG2972 Predicted signal transduction protein with a C-terminal ATPase domain.	LytTR family two component transcriptional regulator; COG3279 Response regulator of the LytR/AlgR family.	0.815
AHM61612.1	AHM62939.1	D770_16790	D770_23470	Putative two-component sensor histidine kinase transcriptional regulator; COG2972 Predicted signal transduction protein with a C-terminal ATPase domain.	LytTR family two component transcriptional regulator; COG3279 Response regulator of the LytR/AlgR family.	0.811
AHM61612.1	AHM63268.1	D770_16790	D770_25115	Putative two-component sensor histidine kinase transcriptional regulator; COG2972 Predicted signal transduction protein with a C-terminal ATPase domain.	LytTR family two component transcriptional regulator; COG3279 Response regulator of the LytR/AlgR family.	0.812
AHM62054.1	AHM61612.1	D770_19015	D770_16790	COG3279 Response regulator of the LytR/AlgR family.	Putative two-component sensor histidine kinase transcriptional regulator; COG2972 Predicted signal transduction protein with a C-terminal ATPase domain.	0.812
AHM62892.1	AHM61612.1	D770_23235	D770_16790	LytTR family two component transcriptional regulator; COG3279 Response regulator of the LytR/AlgR family.	Putative two-component sensor histidine kinase transcriptional regulator; COG2972 Predicted signal transduction protein with a C-terminal ATPase domain.	0.815
AHM62939.1	AHM61612.1	D770_23470	D770_16790	LytTR family two component transcriptional regulator; COG3279 Response regulator of the LytR/AlgR family.	Putative two-component sensor histidine kinase transcriptional regulator; COG2972 Predicted signal transduction protein with a C-terminal ATPase domain.	0.811
AHM63268.1	AHM61612.1	D770_25115	D770_16790	LytTR family two component transcriptional regulator; COG3279 Response regulator of the LytR/AlgR family.	Putative two-component sensor histidine kinase transcriptional regulator; COG2972 Predicted signal transduction protein with a C-terminal ATPase domain.	0.812

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

10

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009097

Isoleucine biosynthetic process

7 of 14

2.26

5.34

2.79e-12

GO:0009099

Valine biosynthetic process

5 of 10

2.26

3.86

1.31e-08

GO:1901607

Alpha-amino acid biosynthetic process

10 of 104

1.55

3.16

1.07e-12

GO:0046394

Carboxylic acid biosynthetic process

11 of 166

1.39

2.55

1.07e-12

GO:0043650

Dicarboxylic acid biosynthetic process

3 of 19

1.76

1.4

0.0012

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000287

Magnesium ion binding

5 of 65

1.45

1.34

0.00046

GO:0019842

Vitamin binding

4 of 46

1.5

1.14

0.0026

GO:0015930

Glutamate synthase activity

2 of 2

2.56

1.12

0.0090

GO:0004455

Ketol-acid reductoisomerase activity

2 of 2

2.56

1.12

0.0090

GO:0050661

NADP binding

3 of 22

1.7

1.01

0.0090

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005948

Acetolactate synthase complex

2 of 2

2.56

1.39

0.0028

GO:0005829

Cytosol

7 of 324

0.9

0.76

0.00080

GO:0005737

Cytoplasm

9 of 1245

0.42

0.29

0.0348

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:993

Branched-chain amino acid metabolic process

6 of 23

1.98

3.5

1.00e-08

CL:924

Branched-chain amino acid metabolic process, and Aspartate family amino acid biosynthetic process

8 of 58

1.7

3.32

2.20e-10

CL:923

Alpha-amino acid biosynthetic process, and Dicarboxylic acid metabolic process

9 of 84

1.59

3.09

5.47e-11

CL:996

Branched-chain amino acid metabolic process

4 of 17

1.94

2.12

3.68e-05

CL:810

Glutamate biosynthetic process, and Ammonia ligase activity

2 of 5

2.17

0.87

0.0239

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00290

Valine, leucine and isoleucine biosynthesis

7 of 22

2.07

4.63

1.56e-11

map00770

Pantothenate and CoA biosynthesis

6 of 21

2.02

3.94

8.68e-10

map01210

2-Oxocarboxylic acid metabolism

6 of 51

1.63

2.58

7.73e-08

map01230

Biosynthesis of amino acids

10 of 159

1.36

2.38

1.56e-11

map00660

C5-Branched dibasic acid metabolism

2 of 10

1.87

1.09

0.0074

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005948

Acetolactate synthase complex

2 of 4

2.26

1.07

0.0102

GOCC:0005737

Cytoplasm

10 of 946

0.59

0.47

0.0014

GOCC:0005622

Intracellular

11 of 1345

0.48

0.39

0.0014

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0100

Branched-chain amino acid biosynthesis

4 of 14

2.02

2.3

1.87e-05

KW-0412

Isoleucine biosynthesis

2 of 3

2.39

1.26

0.0047

KW-0663

Pyridoxal phosphate

3 of 40

1.44

0.92

0.0091

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04898

Glutamate synthase central domain

2 of 2

2.56

0.85

0.0286

PF02776

Thiamine pyrophosphate enzyme, N-terminal TPP binding domain

2 of 2

2.56

0.85

0.0286

PF01645

Conserved region in glutamate synthase

2 of 2

2.56

0.85

0.0286

PF01493

GXGXG motif

2 of 2

2.56

0.85

0.0286

PF01450

Acetohydroxy acid isomeroreductase, catalytic domain

2 of 2

2.56

0.85

0.0286

(more ...)

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