STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACA1_238390Coronin; Belongs to the WD repeat coronin family. (394 aa)    
Predicted Functional Partners:
ACA1_371310
3,4dihydroxy-2-butanone-4-phosphate synthase.
  
 0.867
ACA1_057010
Dihydrofolate reductase; Belongs to the dihydrofolate reductase family.
    
 0.830
ACA1_199730
Dihydrofolate reductase; Belongs to the dihydrofolate reductase family.
    
 0.830
ACA1_193330
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
  
 0.801
ACA1_251350
Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions.
    
 0.752
ACA1_279770
Molybdenum cofactor biosynthesis protein A, putative.
    
 0.647
ACA1_352960
GTPbinding protein.
    
 
 0.615
ACA1_322160
Epoxide hydrolase 2, cytoplasmic, putative.
    
 0.611
ACA1_281460
HAD hydrolase, family IA, variant 3 subfamily protein.
    
 0.611
ACA1_104230
GTP cyclohydrolase, putative.
    
 0.559
Your Current Organism:
Acanthamoeba castellanii
NCBI taxonomy Id: 1257118
Other names: A. castellanii str. Neff, Acanthamoeba castellanii Neff strain, Acanthamoeba castellanii str. Neff, Acanthamoeba castellanii strain Neff
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.