STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACA1_163860Formate-tetrahydrofolate ligase. (631 aa)    
Predicted Functional Partners:
ACA1_270360
Phosphoribosylamine-glycine ligase.
  
 0.999
ACA1_036340
Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.
  
 0.988
ACA1_142370
Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.
  
 0.988
ACA1_057010
Dihydrofolate reductase; Belongs to the dihydrofolate reductase family.
  
 
 0.977
ACA1_199730
Dihydrofolate reductase; Belongs to the dihydrofolate reductase family.
  
 
 0.977
ACA1_187720
Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)binding domain containing protein.
 
 
 0.972
ACA1_099480
Methenyltetrahydrofolate cyclohydrolase.
 
 
 0.972
ACA1_063510
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.971
ACA1_187590
Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)binding domain containing protein.
 
 
 0.965
ACA1_149940
Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.
  
 0.959
Your Current Organism:
Acanthamoeba castellanii
NCBI taxonomy Id: 1257118
Other names: A. castellanii str. Neff, Acanthamoeba castellanii Neff strain, Acanthamoeba castellanii str. Neff, Acanthamoeba castellanii strain Neff
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.