STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACA1_235910SPRY domain containing protein. (556 aa)    
Predicted Functional Partners:
ACA1_063420
WD40 repeat protein, COMPASS complex protein.
    
 0.998
ACA1_091780
SET domain containing protein.
    
 0.948
ACA1_297540
WD domain, G-beta repeat-containing protein.
   
 0.947
ACA1_265870
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
    
 0.945
ACA1_275460
PHDfinger domain containing protein.
   
 0.936
ACA1_279800
PHD-finger domain containing protein.
   
 0.936
ACA1_219790
ARID/BRIGHT DNA binding domain containing protein.
    
 0.895
ACA1_111910
Histone h3, putative.
    
 0.873
ACA1_053350
Histone H3(2), putative.
    
 0.873
ACA1_054940
Histone h3, putative.
    
 0.873
Your Current Organism:
Acanthamoeba castellanii
NCBI taxonomy Id: 1257118
Other names: A. castellanii str. Neff, Acanthamoeba castellanii Neff strain, Acanthamoeba castellanii str. Neff, Acanthamoeba castellanii strain Neff
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.