STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACA1_200240Phospholipase D active site domain containing protein. (1137 aa)    
Predicted Functional Partners:
PSD2
Phosphatidylserine decarboxylase 2 alpha chain; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.
   
 0.943
ACA1_295150
Phosphatidylserine decarboxylase.
   
 0.943
ACA1_203900
Phosphatidylethanolamine Nmethyltransferase.
     
 0.914
ACA1_069380
Lipin, Nterminal containing protein.
    
 0.914
ACA1_091530
Phosphatidylethanolamine N-methyltransferase; Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC); Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
     
 0.908
ACA1_280020
Uncharacterized protein.
     
 0.906
ACA1_295550
Membranebound O-acyltransferase domain containing protein 2, putative; Belongs to the membrane-bound acyltransferase family.
     
 0.906
ACA1_295990
Phosphatidylserine synthase.
     
 0.906
ACA1_219870
Lysophospholipase 3 (Lysosomal phospholipase A2) isoform 7, putative.
     
 0.904
ACA1_052320
Phosphatidylcholinesterol acyltransferase (Lecithin-cholesterol acyltransferase), putative.
     
 0.904
Your Current Organism:
Acanthamoeba castellanii
NCBI taxonomy Id: 1257118
Other names: A. castellanii str. Neff, Acanthamoeba castellanii Neff strain, Acanthamoeba castellanii str. Neff, Acanthamoeba castellanii strain Neff
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