STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACA1_227700Isocitrate dehydrogenase Idp1, putative. (194 aa)    
Predicted Functional Partners:
ACA1_183620
Citrate synthase; Belongs to the citrate synthase family.
  
 0.932
ACA1_268920
Oxoglutarate dehydrogenase (Succinyltransferring), E1 component, putative.
   
 
 0.833
ACA1_283230
Oxoglutarate dehydrogenase (Succinyltransferring), E1 component, putative.
   
 
 0.799
ACA1_359750
Succinyl coenzyme A synthetase alpha subunit; Belongs to the succinate/malate CoA ligase alpha subunit family.
  
  
 0.795
ACA1_376500
Isocitrate dehydrogenase subunit 1, mitochondrial, putative.
  
 
 0.782
ACA1_296490
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
  
 0.780
ACA1_058740
ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
  
  
 0.774
ACA1_061650
Homoaconitase, mitochondrial, putative.
  
 0.743
ACA1_115670
Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.
  
 0.743
ACA1_053890
Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.
  
 0.743
Your Current Organism:
Acanthamoeba castellanii
NCBI taxonomy Id: 1257118
Other names: A. castellanii str. Neff, Acanthamoeba castellanii Neff strain, Acanthamoeba castellanii str. Neff, Acanthamoeba castellanii strain Neff
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.