ACA1_357500 protein (Acanthamoeba castellanii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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Textmining

[Homology]

Score

ACA1_357500

Uncharacterized protein. (287 aa)

Predicted Functional Partners:

ACA1_228650

0.939

ACA1_156200

0.768

ACA1_366350

0.749

ACA1_377410

0.742

ACA1_232820

0.742

ACA1_219460

0.695

ACA1_074420

0.523

ACA1_078040

0.516

ACA1_216360

0.516

ACA1_216370

0.516

Your Current Organism:

Acanthamoeba castellanii

NCBI taxonomy Id: 1257118
Other names: A. castellanii str. Neff, Acanthamoeba castellanii Neff strain, Acanthamoeba castellanii str. Neff, Acanthamoeba castellanii strain Neff

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACA1_074420	ACA1_219460	L8HFC7	L8GSX9	Putative N6adenosine-methyltransferase; Belongs to the MT-A70-like family.	MT-A70 protein; Belongs to the MT-A70-like family.	0.948
ACA1_074420	ACA1_357500	L8HFC7	L8HCC6	Putative N6adenosine-methyltransferase; Belongs to the MT-A70-like family.	Uncharacterized protein.	0.523
ACA1_078040	ACA1_216370	L8GPL8	L8GQ88	Uridine-cytidine kinase; Belongs to the uridine kinase family.	Uridine kinase.	0.916
ACA1_078040	ACA1_228650	L8GPL8	L8H7Y7	Uridine-cytidine kinase; Belongs to the uridine kinase family.	Uncharacterized protein.	0.729
ACA1_078040	ACA1_232820	L8GPL8	L8H0Z3	Uridine-cytidine kinase; Belongs to the uridine kinase family.	Uncharacterized protein.	0.642
ACA1_078040	ACA1_357500	L8GPL8	L8HCC6	Uridine-cytidine kinase; Belongs to the uridine kinase family.	Uncharacterized protein.	0.516
ACA1_078040	ACA1_377410	L8GPL8	L8GRV7	Uridine-cytidine kinase; Belongs to the uridine kinase family.	Uncharacterized protein.	0.642
ACA1_156200	ACA1_219460	L8GIE8	L8GSX9	MT-A70 protein; Belongs to the MT-A70-like family.	MT-A70 protein; Belongs to the MT-A70-like family.	0.953
ACA1_156200	ACA1_357500	L8GIE8	L8HCC6	MT-A70 protein; Belongs to the MT-A70-like family.	Uncharacterized protein.	0.768
ACA1_216360	ACA1_228650	L8GPP5	L8H7Y7	Uridine kinase.	Uncharacterized protein.	0.729
ACA1_216360	ACA1_232820	L8GPP5	L8H0Z3	Uridine kinase.	Uncharacterized protein.	0.642
ACA1_216360	ACA1_357500	L8GPP5	L8HCC6	Uridine kinase.	Uncharacterized protein.	0.516
ACA1_216360	ACA1_377410	L8GPP5	L8GRV7	Uridine kinase.	Uncharacterized protein.	0.642
ACA1_216370	ACA1_078040	L8GQ88	L8GPL8	Uridine kinase.	Uridine-cytidine kinase; Belongs to the uridine kinase family.	0.916
ACA1_216370	ACA1_228650	L8GQ88	L8H7Y7	Uridine kinase.	Uncharacterized protein.	0.729
ACA1_216370	ACA1_232820	L8GQ88	L8H0Z3	Uridine kinase.	Uncharacterized protein.	0.642
ACA1_216370	ACA1_357500	L8GQ88	L8HCC6	Uridine kinase.	Uncharacterized protein.	0.516
ACA1_216370	ACA1_377410	L8GQ88	L8GRV7	Uridine kinase.	Uncharacterized protein.	0.642
ACA1_219460	ACA1_074420	L8GSX9	L8HFC7	MT-A70 protein; Belongs to the MT-A70-like family.	Putative N6adenosine-methyltransferase; Belongs to the MT-A70-like family.	0.948
ACA1_219460	ACA1_156200	L8GSX9	L8GIE8	MT-A70 protein; Belongs to the MT-A70-like family.	MT-A70 protein; Belongs to the MT-A70-like family.	0.953

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.787

expected number of edges:

14

PPI enrichment p-value:

0.0197

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001963

Synaptic transmission, dopaminergic

3 of 14

2.59

1.81

0.00046

GO:0042417

Dopamine metabolic process

3 of 17

2.51

1.78

0.00051

GO:0098810

Neurotransmitter reuptake

3 of 18

2.48

1.77

0.00051

GO:0015844

Monoamine transport

3 of 18

2.48

1.77

0.00051

GO:0007212

Dopamine receptor signaling pathway

3 of 21

2.42

1.76

0.00051

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035240

Dopamine binding

3 of 6

2.96

2.48

3.07e-05

GO:0001591

Dopamine neurotransmitter receptor activity, coupled via Gi/Go

2 of 3

3.08

1.42

0.0027

GO:0015378

Sodium:chloride symporter activity

2 of 9

2.61

1.12

0.0090

GO:0008504

Monoamine transmembrane transporter activity

2 of 9

2.61

1.12

0.0090

GO:0005326

Neurotransmitter transmembrane transporter activity

2 of 14

2.42

1.04

0.0122

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005834

Heterotrimeric G-protein complex

3 of 29

2.28

1.6

0.00094

GO:0036477

Somatodendritic compartment

5 of 589

1.19

0.87

0.0046

GO:0030425

Dendrite

4 of 436

1.22

0.8

0.0104

GO:0098797

Plasma membrane protein complex

4 of 456

1.2

0.79

0.0104

GO:0030424

Axon

4 of 477

1.18

0.78

0.0105

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:26528222

(2015) Genetic influences on insight problem solving: the role of catechol-O-methyltransferase (COMT) gene polymorphisms.

3 of 5

3.04

2.56

2.23e-05

PMID:34072960

(2021) Understanding Emotions: Origins and Roles of the Amygdala.

3 of 12

2.66

2.19

9.02e-05

PMID:29579395

(2018) Polygenic Risk Scores in Clinical Psychology: Bridging Genomic Risk to Individual Differences.

3 of 16

2.53

2.09

0.00013

PMID:33343403

(2020) The Autism Palette: Combinations of Impairments Explain the Heterogeneity in ASD.

2 of 6

2.78

1.22

0.0062

PMID:31616587

(2019) The dopamine receptor D5 gene shows signs of independent erosion in toothed and baleen whales.

2 of 6

2.78

1.22

0.0062

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:35990

Opioid Signalling, and Amine ligand-binding receptors

9 of 86

2.28

6.91

1.90e-16

CL:35991

Opioid Signalling, and Amine ligand-binding receptors

7 of 80

2.2

5.05

7.85e-12

CL:36005

Mixed, incl. Norepinephrine binding, and Mu-type opioid receptor binding

3 of 5

3.04

2.92

4.87e-06

CL:35999

G alpha (z) signalling events, and G-protein beta/gamma-subunit complex binding

4 of 35

2.32

2.81

3.40e-06

CL:36137

Dopamine receptors, and Response to gravity

3 of 7

2.89

2.79

7.83e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

lav04726

Serotonergic synapse

4 of 94

1.89

2.01

5.73e-05

lav04728

Dopaminergic synapse

4 of 101

1.86

1.98

5.73e-05

lav04713

Circadian entrainment

3 of 75

1.86

1.48

0.0010

lav05032

Morphine addiction

3 of 79

1.84

1.47

0.0010

lav04727

GABAergic synapse

3 of 77

1.85

1.47

0.0010

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-112311

Neurotransmitter clearance

3 of 9

2.78

2.53

2.30e-05

MAP-112315

Transmission across Chemical Synapses

6 of 261

1.62

2.12

3.93e-06

MAP-451326

Activation of kainate receptors upon glutamate binding

3 of 32

2.23

1.82

0.00034

MAP-4086398

Ca2+ pathway

3 of 41

2.12

1.68

0.00055

MAP-112316

Neuronal System

6 of 412

1.42

1.65

2.30e-05

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0003954

Dopaminergic system

3 of 4

3.14

2.87

6.19e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005834

Heterotrimeric G-protein complex

3 of 16

2.53

1.99

0.00020

GOCC:0071944

Cell periphery

9 of 4127

0.6

0.44

0.0051

GOCC:0005886

Plasma membrane

8 of 3874

0.58

0.36

0.0304

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0769

Symport

2 of 27

2.13

0.76

0.0383

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR016346

Guanine nucleotide-binding protein, beta subunit

2 of 4

2.96

0.86

0.0279

IPR001632

G-protein, beta subunit

2 of 6

2.78

0.86

0.0279

IPR000929

Dopamine receptor family

2 of 5

2.86

0.86

0.0279

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