STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACA1_149490Biotin/lipoate A/B protein ligase domain containing protein. (251 aa)    
Predicted Functional Partners:
ACA1_173270
Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.
   
 0.929
ACA1_142390
Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 0.838
ACA1_055650
Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
  
 
 0.826
ACA1_095900
Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
  
 
 0.794
ACA1_292910
Branched-chain alpha-KETO ACID decarboxylase E1 beta subunit, putative.
  
 
 0.790
ACA1_295800
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.
  
 0.785
ACA1_055660
Lipoyl(Octanoyl) transferase.
   
 0.783
ACA1_320830
Lipoyl-binding domain-containing protein.
  
 0.763
ACA1_376960
2oxo acid dehydrogenase acyltransferase catalytic subunit.
  
 0.763
ACA1_062090
Dihydrolipoamide dehydrogenase.
  
 
 0.656
Your Current Organism:
Acanthamoeba castellanii
NCBI taxonomy Id: 1257118
Other names: A. castellanii str. Neff, Acanthamoeba castellanii Neff strain, Acanthamoeba castellanii str. Neff, Acanthamoeba castellanii strain Neff
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.