STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACA1_376710PHD-finger domain containing protein. (837 aa)    
Predicted Functional Partners:
ACA1_265870
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
    
 0.744
ACA1_111910
Histone h3, putative.
    
 0.706
ACA1_053350
Histone H3(2), putative.
    
 0.706
ACA1_054940
Histone h3, putative.
    
 0.706
ACA1_295730
Core histone h2a/h2b/h3/h4 superfamily protein.
    
 0.706
ACA1_053360
Zinc finger, domain containing protein.
   
 0.661
ACA1_105940
ARID/BRIGHT DNA binding domain containing protein.
     
 0.627
ACA1_058710
Sphase kinase-associated protein, putative; Belongs to the SKP1 family.
    
 0.615
ACA1_382550
Sulfur metabolism negative regulator SconC, putative; Belongs to the SKP1 family.
    
 0.615
ACA1_385430
S-phase kinase-associated protein 1A isoform b, putative; Belongs to the SKP1 family.
    
 0.615
Your Current Organism:
Acanthamoeba castellanii
NCBI taxonomy Id: 1257118
Other names: A. castellanii str. Neff, Acanthamoeba castellanii Neff strain, Acanthamoeba castellanii str. Neff, Acanthamoeba castellanii strain Neff
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.