ACA1_071980 protein (Acanthamoeba castellanii)

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second shell of interactors

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Edges:

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

ACA1_071980

CCCHtype Zn finger-containing protein. (284 aa)

Predicted Functional Partners:

ACA1_006240

0.995

ACA1_130520

0.992

ACA1_382380

0.992

ACA1_369920

0.991

ACA1_297540

0.988

ACA1_043120

0.983

ACA1_173990

0.971

ACA1_261450

0.960

ACA1_217700

0.959

ACA1_374710

0.958

Your Current Organism:

Acanthamoeba castellanii

NCBI taxonomy Id: 1257118
Other names: A. castellanii str. Neff, Acanthamoeba castellanii Neff strain, Acanthamoeba castellanii str. Neff, Acanthamoeba castellanii strain Neff

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACA1_006240	ACA1_043120	L8HH43	L8GXT8	RNA polymerase II subunit A Cterminal domain phosphatase SSU72, putative.	Putative cleavage and polyadenylation specificity factor, putative.	0.992
ACA1_006240	ACA1_071980	L8HH43	L8HGM2	RNA polymerase II subunit A Cterminal domain phosphatase SSU72, putative.	CCCHtype Zn finger-containing protein.	0.995
ACA1_006240	ACA1_130520	L8HH43	L8GPK4	RNA polymerase II subunit A Cterminal domain phosphatase SSU72, putative.	CPSF A subunit region protein.	0.997
ACA1_006240	ACA1_173990	L8HH43	L8HK22	RNA polymerase II subunit A Cterminal domain phosphatase SSU72, putative.	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	0.981
ACA1_006240	ACA1_217700	L8HH43	L8GQL2	RNA polymerase II subunit A Cterminal domain phosphatase SSU72, putative.	Tetratricopeptide repeat domain containing protein.	0.550
ACA1_006240	ACA1_261450	L8HH43	L8GF72	RNA polymerase II subunit A Cterminal domain phosphatase SSU72, putative.	TrkA Cterminal domain containing protein.	0.969
ACA1_006240	ACA1_297540	L8HH43	L8GGE0	RNA polymerase II subunit A Cterminal domain phosphatase SSU72, putative.	WD domain, G-beta repeat-containing protein.	0.997
ACA1_006240	ACA1_369920	L8HH43	L8GYA6	RNA polymerase II subunit A Cterminal domain phosphatase SSU72, putative.	Cleavage and polyadenylation specificity factor subunit 2.	0.998
ACA1_006240	ACA1_374710	L8HH43	L8GHC6	RNA polymerase II subunit A Cterminal domain phosphatase SSU72, putative.	WD domain, G-beta repeat-containing protein.	0.467
ACA1_006240	ACA1_382380	L8HH43	L8GUA6	RNA polymerase II subunit A Cterminal domain phosphatase SSU72, putative.	WD domain, G-beta repeat-containing protein.	0.983
ACA1_043120	ACA1_006240	L8GXT8	L8HH43	Putative cleavage and polyadenylation specificity factor, putative.	RNA polymerase II subunit A Cterminal domain phosphatase SSU72, putative.	0.992
ACA1_043120	ACA1_071980	L8GXT8	L8HGM2	Putative cleavage and polyadenylation specificity factor, putative.	CCCHtype Zn finger-containing protein.	0.983
ACA1_043120	ACA1_130520	L8GXT8	L8GPK4	Putative cleavage and polyadenylation specificity factor, putative.	CPSF A subunit region protein.	0.992
ACA1_043120	ACA1_173990	L8GXT8	L8HK22	Putative cleavage and polyadenylation specificity factor, putative.	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	0.982
ACA1_043120	ACA1_217700	L8GXT8	L8GQL2	Putative cleavage and polyadenylation specificity factor, putative.	Tetratricopeptide repeat domain containing protein.	0.932
ACA1_043120	ACA1_261450	L8GXT8	L8GF72	Putative cleavage and polyadenylation specificity factor, putative.	TrkA Cterminal domain containing protein.	0.958
ACA1_043120	ACA1_297540	L8GXT8	L8GGE0	Putative cleavage and polyadenylation specificity factor, putative.	WD domain, G-beta repeat-containing protein.	0.989
ACA1_043120	ACA1_369920	L8GXT8	L8GYA6	Putative cleavage and polyadenylation specificity factor, putative.	Cleavage and polyadenylation specificity factor subunit 2.	0.994
ACA1_043120	ACA1_374710	L8GXT8	L8GHC6	Putative cleavage and polyadenylation specificity factor, putative.	WD domain, G-beta repeat-containing protein.	0.876
ACA1_043120	ACA1_382380	L8GXT8	L8GUA6	Putative cleavage and polyadenylation specificity factor, putative.	WD domain, G-beta repeat-containing protein.	0.992

page 1 of 6

Network Stats

number of nodes:

7

number of edges:

11

average node degree:

3.14

avg. local clustering coefficient:

0.833

expected number of edges:

6

PPI enrichment p-value:

0.0509

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0098609

Cell-cell adhesion

7 of 339

1.49

1.91

4.11e-06

GO:0007043

Cell-cell junction assembly

4 of 79

1.88

1.68

0.00035

GO:0016055

Wnt signaling pathway

5 of 174

1.63

1.62

0.00019

GO:0007155

Cell adhesion

8 of 592

1.3

1.6

4.11e-06

GO:0014068

Positive regulation of phosphatidylinositol 3-kinase signaling

3 of 37

2.08

1.4

0.0020

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045296

Cadherin binding

5 of 59

2.1

3.04

4.66e-07

GO:0050839

Cell adhesion molecule binding

7 of 226

1.66

2.62

8.90e-08

GO:0005001

Transmembrane receptor protein tyrosine phosphatase activity

2 of 3

3.0

1.35

0.0036

GO:0045294

Alpha-catenin binding

2 of 9

2.52

1.09

0.0100

GO:0042169

SH2 domain binding

2 of 24

2.09

0.76

0.0392

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005911

Cell-cell junction

7 of 307

1.53

2.22

3.55e-07

GO:0005912

Adherens junction

4 of 112

1.73

1.72

0.00016

GO:0030054

Cell junction

9 of 1317

1.01

1.1

4.42e-06

GO:0014704

Intercalated disc

2 of 17

2.24

1.05

0.0112

GO:0043235

Receptor complex

4 of 283

1.32

0.94

0.0051

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:23177

Catenin complex, and Armadillo/beta-catenin-like repeats

3 of 28

2.2

1.31

0.0034

CL:23185

Catenin complex

2 of 6

2.7

1.27

0.0049

CL:14634

Fz domain, and Positive regulation of fibroblast growth factor production

2 of 5

2.78

1.27

0.0049

CL:236

Mixed, incl. SH2 domain, and phosphatidylinositol-3-phosphate biosynthetic process

3 of 97

1.66

0.99

0.0093

CL:242

SH2 domain, and MET activates PTPN11

2 of 34

1.94

0.76

0.0366

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04520

Adherens junction

5 of 90

1.92

2.81

5.09e-07

map04310

Wnt signaling pathway

4 of 192

1.49

1.34

0.00059

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5218920

VEGFR2 mediated vascular permeability

4 of 29

2.31

2.79

3.68e-06

MAP-418990

Adherens junctions interactions

4 of 39

2.19

2.62

6.07e-06

MAP-421270

Cell-cell junction organization

4 of 56

2.03

2.32

1.74e-05

MAP-1433559

Regulation of KIT signaling

3 of 15

2.48

2.29

5.04e-05

MAP-1500931

Cell-Cell communication

5 of 121

1.79

2.28

6.07e-06

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0393

Immunoglobulin domain

3 of 59

1.88

1.4

0.0015

KW-0675

Receptor

7 of 898

1.07

1.03

0.00015

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01392

Fz domain

2 of 3

3.0

1.16

0.0081

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00185

Armadillo/beta-catenin-like repeats

4 of 31

2.28

2.75

4.19e-06

SM00219

Tyrosine kinase, catalytic domain

4 of 79

1.88

1.96

7.24e-05

SM00408

Immunoglobulin C-2 Type

4 of 161

1.57

1.36

0.00076

SM00130

Kringle domain

2 of 14

2.33

1.1

0.0091

SM00194

Protein tyrosine phosphatase, catalytic domain

2 of 38

1.9

0.7

0.0467

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