Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
D920_00789Transporter, major facilitator family protein; KEGG: ssr:SALIVB_1450 3.2e-116 coaE; Dephospho-CoA kinase; Psort location: CytoplasmicMembrane, score: 10.00. (398 aa)    
Predicted Functional Partners:
D920_00788
Putative permease; KEGG: btk:BT9727_0241 1.9e-86 guanine-hypoxanthine permease; xanthine/uracil permease family protein K06901; Psort location: CytoplasmicMembrane, score: 10.00.
     
 0.995
D920_00787
Cof-like hydrolase; KEGG: efc:EFAU004_01297 9.3e-110 HAD superfamily hydrolase K07024; Psort location: Cytoplasmic, score: 7.50.
  
  
 0.992
D920_02599
Ornithine cyclodeaminase/mu-crystallin family protein; KEGG: efu:HMPREF0351_12084 1.9e-102 ornithine cyclodeaminase K01750; Psort location: Cytoplasmic, score: 7.50.
  
  
 0.946
mutM
DNA-formamidopyrimidine glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
 
   
 0.933
guaA
GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP.
     
 0.931
polA
DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
     
 0.926
D920_02448
Cysteine synthase A; KEGG: efc:EFAU004_01006 6.6e-132 cysteine synthase A K01738; Psort location: Cytoplasmic, score: 7.50; Belongs to the cysteine synthase/cystathionine beta- synthase family.
  
  
 0.925
D920_02953
Putative undecaprenol kinase; KEGG: efc:EFAU004_01992 5.3e-52 diacylglycerol kinase K00901; Psort location: CytoplasmicMembrane, score: 10.00.
  
  
 0.925
smpB
SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...]
     
 0.922
D920_00643
Preprotein translocase, SecG subunit; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family.
  
  
 0.921
Your Current Organism:
Enterococcus faecalis 13SDW01
NCBI taxonomy Id: 1260356
Other names: E. faecalis 13-SD-W-01, Enterococcus faecalis 13-SD-W-01
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