Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
rex-2CoA binding domain protein; Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. (191 aa)    
Predicted Functional Partners:
thiI
Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
     
 0.994
D920_00901
KEGG: efu:HMPREF0351_10204 0. aad; aldehyde-alcohol dehydrogenase K04072; Psort location: Cytoplasmic, score: 9.97; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
  
  
 0.992
D920_01465
Aminotransferase, class V; KEGG: efu:HMPREF0351_12189 8.3e-173 iscS2; pyridoxal phosphate-dependent transferase K04487; Psort location: Cytoplasmic, score: 9.97.
       0.991
ezrA
Septation ring formation regulator EzrA; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family.
       0.991
valS
valine--tRNA ligase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
     
 0.990
D920_01967
Pyruvate synthase; KEGG: efu:HMPREF0351_11628 0. nifJ; pyruvate synthase K03737; Psort location: Cytoplasmic, score: 7.50.
  
  
 0.972
D920_01456
KEGG: apb:SAR116_0666 2.3e-19 DNA repair protein RadC K03630; Psort location: Cytoplasmic, score: 7.50; Belongs to the UPF0758 family.
     
 0.961
D920_01458
Protein FolC; KEGG: efu:HMPREF0351_12184 8.3e-173 folC; tetrahydrofolate synthase K11754; Psort location: Cytoplasmic, score: 7.50.
     
 0.961
guaA
GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP.
  
  
 0.960
groS
Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
     
 0.958
Your Current Organism:
Enterococcus faecalis 13SDW01
NCBI taxonomy Id: 1260356
Other names: E. faecalis 13-SD-W-01, Enterococcus faecalis 13-SD-W-01
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