Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mecANegative regulator of genetic competence; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. (216 aa)    
Predicted Functional Partners:
D920_01849
Competence protein CoiA-like protein; Psort location: Cytoplasmic, score: 7.50.
 
   
 0.997
D920_01851
ArsC family protein; KEGG: efa:EF2678 1.1e-37 hypothetical protein; K00537 arsenate reductase; Psort location: Cytoplasmic, score: 7.50; Belongs to the ArsC family.
 
  
 0.997
D920_01847
KEGG: efu:HMPREF0351_12421 3.7e-280 pepF; M03 family oligopeptidase F K08602; Psort location: Cytoplasmic, score: 9.97.
     
 0.994
ddl
D-ala D-ala ligase protein; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family.
     
 0.974
D920_01399
Metallo-beta-lactamase domain protein; KEGG: efu:HMPREF0351_10757 3.0e-104 metal-dependent hydrolase; Psort location: Cytoplasmic, score: 7.50.
 
   
 0.968
D920_00763
KEGG: efc:EFAU004_01784 9.9e-193 NADP-specific glutamate dehydrogenase K00262; Psort location: Cytoplasmic, score: 9.97; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
       0.960
uppP
Undecaprenyl-diphosphatase UppP; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family.
     
 0.956
D920_01272
Negative regulator of genetic competence ClpC/MecB; KEGG: snc:HMPREF0837_11672 4.6e-282 clpE; ATP dependent protease K03697; Psort location: Cytoplasmic, score: 9.89; Belongs to the ClpA/ClpB family.
   
 
 0.939
clpP
ATP-dependent Clp endopeptidase, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
   
 
 0.939
D920_01697
Negative regulator of genetic competence ClpC/MecB; KEGG: saa:SAUSA300_0510 5.1e-244 clpC; endopeptidase K03696; Psort location: Cytoplasmic, score: 9.95; Belongs to the ClpA/ClpB family.
   
 
 0.939
Your Current Organism:
Enterococcus faecalis 13SDW01
NCBI taxonomy Id: 1260356
Other names: E. faecalis 13-SD-W-01, Enterococcus faecalis 13-SD-W-01
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