Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
D920_01860RelA/SpoT domain protein; KEGG: sud:ST398NM01_2559 5.5e-41 GTP pyrophosphokinase; Psort location: Cytoplasmic, score: 7.50. (231 aa)    
Predicted Functional Partners:
nadK
NAD(+)/NADH kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
    0.942
D920_02067
ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; KEGG: efu:HMPREF0351_11400 1.7e-156 ciaH; sensor histidine kinase K14982; Psort location: CytoplasmicMembrane, score: 10.00.
     
 0.921
D920_01842
Pseudouridine synthase, RluA family; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family.
     
 0.913
rex
Putative redox-sensing transcriptional repressor rex; Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
     
 0.912
prs-2
Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
  
    0.907
D920_00525
KEGG: efu:HMPREF0351_10676 1.7e-156 pta; phosphate acetyltransferase K00625; Psort location: Cytoplasmic, score: 7.50.
  
    0.904
D920_01280
A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.
       0.902
D920_01845
Adenylate cyclase; KEGG: efu:HMPREF0351_12418 5.7e-55 cyaA; adenylate cyclase; Psort location: Cytoplasmic, score: 7.50.
       0.902
D920_01846
Hypothetical protein; KEGG: efu:HMPREF0351_12419 1.3e-78 dithiol-disulfide isomerase; Psort location: Cytoplasmic, score: 7.50.
       0.902
D920_03078
Hypothetical protein.
       0.902
Your Current Organism:
Enterococcus faecalis 13SDW01
NCBI taxonomy Id: 1260356
Other names: E. faecalis 13-SD-W-01, Enterococcus faecalis 13-SD-W-01
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