Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
D920_02035Hypothetical protein; KEGG: ctc:CTC01157 5.3e-07 phosphoesterase K01175; Psort location: CytoplasmicMembrane, score: 9.55. (67 aa)    
Predicted Functional Partners:
mprF-2
Hypothetical protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.
  
    0.997
D920_02034
Lipid kinase, YegS/Rv2252/BmrU family; KEGG: efc:EFAU004_01539 1.1e-99 diacylglycerol kinase catalytic subunit K07029; Psort location: Cytoplasmic, score: 7.50.
  
    0.995
D920_02032
Dinuclear metal center protein, YbgI family; KEGG: hip:CGSHiEE_02770 1.7e-14 seryl-tRNA synthetase; Psort location: Cytoplasmic, score: 7.50; Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
       0.994
pepT
Peptidase T; Cleaves the N-terminal amino acid of tripeptides. Belongs to the peptidase M20B family.
       0.994
D920_02031
Hypothetical protein; KEGG: efc:EFAU004_01542 1.6e-80 SAM-dependent methyltransferase family protein K06967; Psort location: Cytoplasmic, score: 7.50.
       0.993
clpB
ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.
       0.990
D920_00739
GAF domain protein; KEGG: kla:KLLA0F26587g 9.4e-30 hypothetical protein; K08968 L-methionine (R)-S-oxide reductase; Psort location: Cytoplasmic, score: 7.50.
       0.967
udk
Uridine kinase; KEGG: ehr:EHR_03945 2.7e-103 uridine/cytidine kinase; Psort location: Cytoplasmic, score: 9.97.
       0.967
D920_01342
DEAD/DEAH box helicase; KEGG: thl:TEH_16770 6.6e-109 putative RNA helicase; Psort location: Cytoplasmic, score: 9.97.
       0.967
dnaX
DNA polymerase III, subunit gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
       0.967
Your Current Organism:
Enterococcus faecalis 13SDW01
NCBI taxonomy Id: 1260356
Other names: E. faecalis 13-SD-W-01, Enterococcus faecalis 13-SD-W-01
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