Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
D920_020863-deoxy-7-phosphoheptulonate synthase; KEGG: efc:EFAU004_01582 3.3e-146 phospho-2-dehydro-3-deoxyheptonate aldolase K03856; Psort location: Cytoplasmic, score: 9.97. (341 aa)    
Predicted Functional Partners:
aroK
Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.
 
  
 0.999
aroA
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
 
  
 0.999
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
  
 0.999
aroB
3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
 
  
 0.999
aroE
Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
 
  
 0.999
D920_02081
Cell envelope-like function transcriptional attenuator common domain protein; Psort location: CytoplasmicMembrane, score: 9.51.
       0.995
D920_00956
Chorismate mutase; KEGG: efc:EFAU004_00196 1.2e-100 maltose O-acetyltransferase K00661; Psort location: Cytoplasmic, score: 9.67.
  
  
 0.992
D920_02121
EDD domain protein, DegV family; KEGG: mgf:MGF_3873 1.2e-22 DegV-like protein.
       0.991
D920_02393
ABC transporter, ATP-binding protein; KEGG: efu:HMPREF0351_11368 1.9e-111 ABC superfamily ATP binding cassette transporter, ABC protein K05833; Psort location: CytoplasmicMembrane, score: 8.78.
       0.987
D920_02394
Branched-chain amino acid ABC transporter, permease protein; KEGG: nth:Nther_2686 8.9e-18 monosaccharide-transporting ATPase K10440; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the binding-protein-dependent transport system permease family.
       0.987
Your Current Organism:
Enterococcus faecalis 13SDW01
NCBI taxonomy Id: 1260356
Other names: E. faecalis 13-SD-W-01, Enterococcus faecalis 13-SD-W-01
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