Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
D920_02473Transporter, small conductance mechanosensitive ion channel MscS family protein; KEGG: mla:Mlab_1701 7.9e-09 phosphoglycerate mutase K01834; Psort location: CytoplasmicMembrane, score: 10.00. (305 aa)    
Predicted Functional Partners:
D920_02472
KEGG: efu:HMPREF0351_11294 8.3e-173 ilvE; branched-chain-amino-acid transaminase K00826; Psort location: Cytoplasmic, score: 7.50.
     
 0.995
D920_02471
Putative enoyl-[acyl-carrier-protein] reductase; KEGG: efu:HMPREF0351_11295 5.1e-118 fabI; enoyl-ACP reductase K00208; Psort location: CytoplasmicMembrane, score: 8.78.
       0.991
ribA
GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family.
  
  
 0.989
polA
DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
     
 0.980
mscL
Large conductance mechanosensitive channel protein; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
     
 0.978
D920_00698
Hypothetical protein.
 
    0.974
tig
Trigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily.
 
     0.971
rpoE
DNA-directed RNA polymerase, delta subunit; Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; Belongs to the RpoE family.
       0.965
D920_00700
Hypothetical protein; KEGG: smp:SMAC_06805 4.8e-11 hypothetical protein; K00728 dolichyl-phosphate-mannose-protein mannosyltransferase.
  
    0.965
D920_01988
Chloride transporter, ClC family; KEGG: ssr:SALIVB_1179 3.8e-113 ribonuclease HII; Psort location: CytoplasmicMembrane, score: 10.00.
     
 0.965
Your Current Organism:
Enterococcus faecalis 13SDW01
NCBI taxonomy Id: 1260356
Other names: E. faecalis 13-SD-W-01, Enterococcus faecalis 13-SD-W-01
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