Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
D920_02491Hypothetical protein; Psort location: CytoplasmicMembrane, score: 9.55. (170 aa)    
Predicted Functional Partners:
D920_02492
Hypothetical protein.
       0.995
D920_02830
Hypothetical protein; Psort location: Cytoplasmic, score: 7.50.
       0.991
D920_02831
Putative Na+/H+ antiporter; KEGG: tgo:TGME49_105180 2.4e-17 sodium/hydrogen exchanger, putative; Psort location: CytoplasmicMembrane, score: 10.00.
       0.991
D920_02121
EDD domain protein, DegV family; KEGG: mgf:MGF_3873 1.2e-22 DegV-like protein.
       0.982
D920_02833
ABC transporter, ATP-binding protein; KEGG: efu:HMPREF0351_11121 5.6e-277 ABC superfamily ATP binding cassette transporter, ABC protein K15738; Psort location: Cytoplasmic, score: 9.95.
       0.981
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
       0.978
D920_02495
Hypothetical protein.
       0.965
D920_02081
Cell envelope-like function transcriptional attenuator common domain protein; Psort location: CytoplasmicMembrane, score: 9.51.
       0.957
D920_02684
Dihydrofolate reductase; KEGG: efu:HMPREF0351_11715 1.3e-64 folA; dihydrofolate reductase K00287; Psort location: Cytoplasmic, score: 7.50.
       0.909
D920_02835
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
       0.909
Your Current Organism:
Enterococcus faecalis 13SDW01
NCBI taxonomy Id: 1260356
Other names: E. faecalis 13-SD-W-01, Enterococcus faecalis 13-SD-W-01
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