Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
D920_02829Hypothetical protein; Psort location: Cytoplasmic, score: 7.50. (151 aa)    
Predicted Functional Partners:
D920_00543
NAD(P)H quinone oxidoreductase, PIG3 family; KEGG: efu:HMPREF0351_10690 4.1e-123 alcohol dehydrogenase; Psort location: Cytoplasmic, score: 9.97.
       0.991
D920_02821
KEGG: efc:EFAU004_01200 1.6e-41 MazG nucleotide pyrophosphohydrolase domain-containing protein; Psort location: Cytoplasmic, score: 7.50.
       0.991
cca
Putative tRNA adenylyltransferase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
       0.991
D920_02833
ABC transporter, ATP-binding protein; KEGG: efu:HMPREF0351_11121 5.6e-277 ABC superfamily ATP binding cassette transporter, ABC protein K15738; Psort location: Cytoplasmic, score: 9.95.
       0.988
D920_02881
Hypothetical protein; KEGG: ssr:SALIVB_2089 3.4e-09 tyrosyl-tRNA synthetase; Psort location: CytoplasmicMembrane, score: 10.00.
       0.967
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
       0.954
D920_02830
Hypothetical protein; Psort location: Cytoplasmic, score: 7.50.
       0.952
D920_02819
Tetratricopeptide repeat protein; KEGG: bya:BANAU_2226 1.2e-52 ypiA; UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase 110 kDa subunit; Psort location: Cytoplasmic, score: 7.50.
       0.938
D920_02835
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
       0.936
D920_02831
Putative Na+/H+ antiporter; KEGG: tgo:TGME49_105180 2.4e-17 sodium/hydrogen exchanger, putative; Psort location: CytoplasmicMembrane, score: 10.00.
       0.917
Your Current Organism:
Enterococcus faecalis 13SDW01
NCBI taxonomy Id: 1260356
Other names: E. faecalis 13-SD-W-01, Enterococcus faecalis 13-SD-W-01
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