Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
D920_02830Hypothetical protein; Psort location: Cytoplasmic, score: 7.50. (91 aa)    
Predicted Functional Partners:
D920_02831
Putative Na+/H+ antiporter; KEGG: tgo:TGME49_105180 2.4e-17 sodium/hydrogen exchanger, putative; Psort location: CytoplasmicMembrane, score: 10.00.
       0.997
D920_02833
ABC transporter, ATP-binding protein; KEGG: efu:HMPREF0351_11121 5.6e-277 ABC superfamily ATP binding cassette transporter, ABC protein K15738; Psort location: Cytoplasmic, score: 9.95.
       0.996
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
       0.996
D920_02491
Hypothetical protein; Psort location: CytoplasmicMembrane, score: 9.55.
       0.991
rbfA
Ribosome-binding factor A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.
       0.981
truB
tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
       0.980
D920_02619
KEGG: efc:EFAU004_01710 1.4e-131 ribF; riboflavin biosynthesis protein RibF K11753; Psort location: Cytoplasmic, score: 7.50.
       0.973
D920_02688
Penicillin-binding protein, transpeptidase domain protein; KEGG: efu:HMPREF0351_10994 0. pbp2B; penicillin-binding protein K00687; Psort location: CytoplasmicMembrane, score: 9.51.
       0.970
D920_02835
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
       0.967
infB
Translation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
       0.959
Your Current Organism:
Enterococcus faecalis 13SDW01
NCBI taxonomy Id: 1260356
Other names: E. faecalis 13-SD-W-01, Enterococcus faecalis 13-SD-W-01
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