Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
D920_02932KEGG: cje:Cj0436 1.6e-09 pyridoxamine 5'-phosphate oxidase; Psort location: Cytoplasmic, score: 7.50. (134 aa)    
Predicted Functional Partners:
D920_02613
KEGG: efi:OG1RF_10412 2.1e-158 ABC superfamily ATP binding cassette transporter, membrane protein K05845:K05846; Psort location: CytoplasmicMembrane, score: 10.00.
       0.968
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
       0.956
D920_03065
DNA topoisomerase; KEGG: efu:HMPREF0351_10562 0. topB; DNA topoisomerase TopB K03169; Psort location: Cytoplasmic, score: 9.64.
       0.956
D920_00957
KEGG: efu:HMPREF0351_10155 5.6e-80 Sir2 family transcriptional regulator K12410; Psort location: Cytoplasmic, score: 7.50.
       0.904
D920_01326
YihY family protein; KEGG: efu:HMPREF0351_10890 3.1e-118 rbn; ribonuclease BN K07058; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the UPF0761 family.
       0.895
D920_02804
Hypothetical protein; Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins; Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family.
       0.885
D920_02295
NAD dependent epimerase/dehydratase family protein; KEGG: efu:HMPREF0351_12357 1.5e-72 flavin reductase K07118.
       0.882
D920_00800
Putative HTH-type transcriptional activator HxlR.
       0.870
D920_02486
Transcriptional regulator, HxlR family; Psort location: Cytoplasmic, score: 7.50.
       0.870
D920_00910
Choline ABC transporter, ATP-binding protein OpuBA; KEGG: efu:HMPREF0351_10198 3.6e-179 opuAA; glycine/betaine/carnitine/choline ABC superfamily ATP binding cassette transporter, ABC protein K05847; Psort location: CytoplasmicMembrane, score: 8.78.
       0.840
Your Current Organism:
Enterococcus faecalis 13SDW01
NCBI taxonomy Id: 1260356
Other names: E. faecalis 13-SD-W-01, Enterococcus faecalis 13-SD-W-01
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.