node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KXI10489.1 | dnaN | HMPREF3195_01808 | HMPREF3195_00916 | FtsK/SpoIIIE family protein; KEGG: pen:PSEEN2212 9.0e-112 ftsK; cell division protein FtsK K03466; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the FtsK/SpoIIIE/SftA family. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.468 |
KXI10489.1 | guaA | HMPREF3195_01808 | HMPREF3195_01231 | FtsK/SpoIIIE family protein; KEGG: pen:PSEEN2212 9.0e-112 ftsK; cell division protein FtsK K03466; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the FtsK/SpoIIIE/SftA family. | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | 0.457 |
KXI10489.1 | polA | HMPREF3195_01808 | HMPREF3195_00575 | FtsK/SpoIIIE family protein; KEGG: pen:PSEEN2212 9.0e-112 ftsK; cell division protein FtsK K03466; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the FtsK/SpoIIIE/SftA family. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.636 |
KXI10489.1 | rarA | HMPREF3195_01808 | HMPREF3195_00217 | FtsK/SpoIIIE family protein; KEGG: pen:PSEEN2212 9.0e-112 ftsK; cell division protein FtsK K03466; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the FtsK/SpoIIIE/SftA family. | ATPase, AAA family; Psort location: Cytoplasmic, score: 7.50. | 0.698 |
KXI10489.1 | topA | HMPREF3195_01808 | HMPREF3195_00215 | FtsK/SpoIIIE family protein; KEGG: pen:PSEEN2212 9.0e-112 ftsK; cell division protein FtsK K03466; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the FtsK/SpoIIIE/SftA family. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.514 |
cinA | guaA | HMPREF3195_01548 | HMPREF3195_01231 | Competence/damage-inducible protein CinA domain protein; KEGG: cco:CCC13826_0279 1.6e-17 fadD; long-chain-fatty-acid--CoA ligase K03743; Psort location: Cytoplasmic, score: 7.50; Belongs to the CinA family. | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | 0.412 |
cinA | mnmA | HMPREF3195_01548 | HMPREF3195_00219 | Competence/damage-inducible protein CinA domain protein; KEGG: cco:CCC13826_0279 1.6e-17 fadD; long-chain-fatty-acid--CoA ligase K03743; Psort location: Cytoplasmic, score: 7.50; Belongs to the CinA family. | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. | 0.438 |
cinA | polA | HMPREF3195_01548 | HMPREF3195_00575 | Competence/damage-inducible protein CinA domain protein; KEGG: cco:CCC13826_0279 1.6e-17 fadD; long-chain-fatty-acid--CoA ligase K03743; Psort location: Cytoplasmic, score: 7.50; Belongs to the CinA family. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.628 |
cinA | rarA | HMPREF3195_01548 | HMPREF3195_00217 | Competence/damage-inducible protein CinA domain protein; KEGG: cco:CCC13826_0279 1.6e-17 fadD; long-chain-fatty-acid--CoA ligase K03743; Psort location: Cytoplasmic, score: 7.50; Belongs to the CinA family. | ATPase, AAA family; Psort location: Cytoplasmic, score: 7.50. | 0.547 |
cinA | rpsP | HMPREF3195_01548 | HMPREF3195_01332 | Competence/damage-inducible protein CinA domain protein; KEGG: cco:CCC13826_0279 1.6e-17 fadD; long-chain-fatty-acid--CoA ligase K03743; Psort location: Cytoplasmic, score: 7.50; Belongs to the CinA family. | Ribosomal protein S16; KEGG: apb:SAR116_1817 3.8e-17 30S ribosomal protein S16 K02959; Psort location: Cytoplasmic, score: 9.95; Belongs to the bacterial ribosomal protein bS16 family. | 0.623 |
codY | cymR | HMPREF3195_00216 | HMPREF3195_00218 | GTP-sensing transcriptional pleiotropic repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | Putative HTH-type transcriptional regulator IscR; Psort location: Cytoplasmic, score: 7.50. | 0.456 |
codY | rarA | HMPREF3195_00216 | HMPREF3195_00217 | GTP-sensing transcriptional pleiotropic repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | ATPase, AAA family; Psort location: Cytoplasmic, score: 7.50. | 0.533 |
codY | topA | HMPREF3195_00216 | HMPREF3195_00215 | GTP-sensing transcriptional pleiotropic repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.726 |
cymR | codY | HMPREF3195_00218 | HMPREF3195_00216 | Putative HTH-type transcriptional regulator IscR; Psort location: Cytoplasmic, score: 7.50. | GTP-sensing transcriptional pleiotropic repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | 0.456 |
cymR | mnmA | HMPREF3195_00218 | HMPREF3195_00219 | Putative HTH-type transcriptional regulator IscR; Psort location: Cytoplasmic, score: 7.50. | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. | 0.581 |
cymR | rarA | HMPREF3195_00218 | HMPREF3195_00217 | Putative HTH-type transcriptional regulator IscR; Psort location: Cytoplasmic, score: 7.50. | ATPase, AAA family; Psort location: Cytoplasmic, score: 7.50. | 0.641 |
dnaN | KXI10489.1 | HMPREF3195_00916 | HMPREF3195_01808 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | FtsK/SpoIIIE family protein; KEGG: pen:PSEEN2212 9.0e-112 ftsK; cell division protein FtsK K03466; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the FtsK/SpoIIIE/SftA family. | 0.468 |
dnaN | polA | HMPREF3195_00916 | HMPREF3195_00575 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.999 |
dnaN | rarA | HMPREF3195_00916 | HMPREF3195_00217 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | ATPase, AAA family; Psort location: Cytoplasmic, score: 7.50. | 0.569 |
dnaN | topA | HMPREF3195_00916 | HMPREF3195_00215 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.753 |