STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
polCDNA polymerase III, alpha subunit; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1440 aa)    
Predicted Functional Partners:
dnaN
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
    
 0.939
dnaX
DNA polymerase III, subunit gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
   
 0.921
dnaX_1
DNA polymerase III subunit gamma and tau domain protein; KEGG: cdl:CDR20291_3384 2.0e-68 DNA polymerase III subunit delta; K02341 DNA polymerase III subunit delta'; Psort location: Cytoplasmic, score: 7.50.
   
 0.915
KXI12465.1
DNA polymerase III, alpha subunit; KEGG: cdl:CDR20291_3218 0. dnaE; DNA polymerase III DnaE; K02337 DNA polymerase III subunit alpha; Psort location: Cytoplasmic, score: 9.97.
    
0.914
KXI11591.1
KEGG: cdg:CDBI1_12030 8.2e-79 DNA polymerase III, delta subunit; K02340 DNA polymerase III subunit delta; Psort location: Cytoplasmic, score: 7.50.
    
 0.914
KXI14362.1
KEGG: cdg:CDBI1_11605 1.3e-57 DNA polymerase III subunit epsilon; K02342 DNA polymerase III subunit epsilon; Psort location: Cytoplasmic, score: 9.97.
  
  
 
0.652
KXI11621.1
Helix-turn-helix protein; Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.
 
     0.650
KXI14051.1
Hydrolase, HD family; KEGG: bqy:MUS_2859 6.4e-31 nadD; putative nicotinate-nucleotide adenylyltransferase; Psort location: Cytoplasmic, score: 7.50.
  
     0.645
tmcAL
Hypothetical protein; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac- AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
  
    0.636
KXI11609.1
Hypothetical protein; KEGG: fnu:FN1387 1.3e-25 metal dependent hydrolase K01567; Psort location: Cytoplasmic, score: 7.50.
       0.590
Your Current Organism:
Peptostreptococcus anaerobius
NCBI taxonomy Id: 1261
Other names: ATCC 27337, CCUG 7835, CIP 104411, DSM 2949, LMG 15865, LMG:15865, NCTC 11460, P. anaerobius, Streptococcus anaerob, Streptococcus anaerobius, VPI 4330
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.