node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFM96883.1 | SFM98871.1 | SAMN05421832_11047 | SAMN05421832_110154 | Dihydrofolate reductase. | Homocysteine S-methyltransferase. | 0.810 |
SFM96883.1 | SFM98885.1 | SAMN05421832_11047 | SAMN05421832_110155 | Dihydrofolate reductase. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.731 |
SFM96883.1 | SFN08680.1 | SAMN05421832_11047 | SAMN05421832_11450 | Dihydrofolate reductase. | Uncharacterized conserved protein YdeI, YjbR/CyaY-like superfamily, DUF1801 family. | 0.650 |
SFM96883.1 | SFN17241.1 | SAMN05421832_11047 | SAMN05421832_1188 | Dihydrofolate reductase. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.824 |
SFM96883.1 | SFN17348.1 | SAMN05421832_11047 | SAMN05421832_11815 | Dihydrofolate reductase. | Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.691 |
SFM96883.1 | gcvH | SAMN05421832_11047 | SAMN05421832_10470 | Dihydrofolate reductase. | Glycine cleavage system H protein; Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate; Belongs to the GcvH family. | 0.691 |
SFM96883.1 | gcvT | SAMN05421832_11047 | SAMN05421832_12122 | Dihydrofolate reductase. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.690 |
SFM96883.1 | glyA | SAMN05421832_11047 | SAMN05421832_101338 | Dihydrofolate reductase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.660 |
SFM96883.1 | thyA | SAMN05421832_11047 | SAMN05421832_103272 | Dihydrofolate reductase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.918 |
SFM96883.1 | tmk | SAMN05421832_11047 | SAMN05421832_1173 | Dihydrofolate reductase. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.650 |
SFM98871.1 | SFM96883.1 | SAMN05421832_110154 | SAMN05421832_11047 | Homocysteine S-methyltransferase. | Dihydrofolate reductase. | 0.810 |
SFM98871.1 | SFM98885.1 | SAMN05421832_110154 | SAMN05421832_110155 | Homocysteine S-methyltransferase. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.999 |
SFM98871.1 | SFN17241.1 | SAMN05421832_110154 | SAMN05421832_1188 | Homocysteine S-methyltransferase. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.518 |
SFM98871.1 | SFN17348.1 | SAMN05421832_110154 | SAMN05421832_11815 | Homocysteine S-methyltransferase. | Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.822 |
SFM98871.1 | gcvH | SAMN05421832_110154 | SAMN05421832_10470 | Homocysteine S-methyltransferase. | Glycine cleavage system H protein; Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate; Belongs to the GcvH family. | 0.848 |
SFM98871.1 | gcvT | SAMN05421832_110154 | SAMN05421832_12122 | Homocysteine S-methyltransferase. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.888 |
SFM98871.1 | glyA | SAMN05421832_110154 | SAMN05421832_101338 | Homocysteine S-methyltransferase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.884 |
SFM98871.1 | thyA | SAMN05421832_110154 | SAMN05421832_103272 | Homocysteine S-methyltransferase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.839 |
SFM98885.1 | SFM96883.1 | SAMN05421832_110155 | SAMN05421832_11047 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Dihydrofolate reductase. | 0.731 |
SFM98885.1 | SFM98871.1 | SAMN05421832_110155 | SAMN05421832_110154 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homocysteine S-methyltransferase. | 0.999 |