node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFM81159.1 | SFN14733.1 | SAMN05421832_10767 | SAMN05421832_11692 | 23S rRNA (guanosine2251-2'-O)-methyltransferase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | 23S rRNA pseudouridine1911/1915/1917 synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. | 0.890 |
SFM81159.1 | dnaJ | SAMN05421832_10767 | SAMN05421832_11245 | 23S rRNA (guanosine2251-2'-O)-methyltransferase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.861 |
SFM81159.1 | obg | SAMN05421832_10767 | SAMN05421832_11843 | 23S rRNA (guanosine2251-2'-O)-methyltransferase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | GTP-binding protein; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | 0.634 |
SFM81159.1 | rplC | SAMN05421832_10767 | SAMN05421832_10742 | 23S rRNA (guanosine2251-2'-O)-methyltransferase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Large subunit ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. | 0.877 |
SFM81159.1 | rplM | SAMN05421832_10767 | SAMN05421832_10710 | 23S rRNA (guanosine2251-2'-O)-methyltransferase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Large subunit ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | 0.925 |
SFM81159.1 | rplO | SAMN05421832_10767 | SAMN05421832_10723 | 23S rRNA (guanosine2251-2'-O)-methyltransferase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Large subunit ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. | 0.880 |
SFM81159.1 | rplQ | SAMN05421832_10767 | SAMN05421832_10715 | 23S rRNA (guanosine2251-2'-O)-methyltransferase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Large subunit ribosomal protein L17. | 0.882 |
SFM81159.1 | rplU | SAMN05421832_10767 | SAMN05421832_11839 | 23S rRNA (guanosine2251-2'-O)-methyltransferase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Large subunit ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. | 0.887 |
SFM81159.1 | rsfS | SAMN05421832_10767 | SAMN05421832_11260 | 23S rRNA (guanosine2251-2'-O)-methyltransferase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Ribosome-associated protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.875 |
SFN00698.1 | SFN14733.1 | SAMN05421832_11150 | SAMN05421832_11692 | RNA methyltransferase, TrmH family; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | 23S rRNA pseudouridine1911/1915/1917 synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. | 0.866 |
SFN00698.1 | dnaJ | SAMN05421832_11150 | SAMN05421832_11245 | RNA methyltransferase, TrmH family; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.860 |
SFN00698.1 | obg | SAMN05421832_11150 | SAMN05421832_11843 | RNA methyltransferase, TrmH family; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | GTP-binding protein; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | 0.597 |
SFN00698.1 | rplC | SAMN05421832_11150 | SAMN05421832_10742 | RNA methyltransferase, TrmH family; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Large subunit ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. | 0.864 |
SFN00698.1 | rplM | SAMN05421832_11150 | SAMN05421832_10710 | RNA methyltransferase, TrmH family; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Large subunit ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | 0.910 |
SFN00698.1 | rplO | SAMN05421832_11150 | SAMN05421832_10723 | RNA methyltransferase, TrmH family; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Large subunit ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. | 0.867 |
SFN00698.1 | rplQ | SAMN05421832_11150 | SAMN05421832_10715 | RNA methyltransferase, TrmH family; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Large subunit ribosomal protein L17. | 0.869 |
SFN00698.1 | rplU | SAMN05421832_11150 | SAMN05421832_11839 | RNA methyltransferase, TrmH family; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Large subunit ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. | 0.870 |
SFN00698.1 | rsfS | SAMN05421832_11150 | SAMN05421832_11260 | RNA methyltransferase, TrmH family; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Ribosome-associated protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.880 |
SFN14733.1 | SFM81159.1 | SAMN05421832_11692 | SAMN05421832_10767 | 23S rRNA pseudouridine1911/1915/1917 synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. | 23S rRNA (guanosine2251-2'-O)-methyltransferase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | 0.890 |
SFN14733.1 | SFN00698.1 | SAMN05421832_11692 | SAMN05421832_11150 | 23S rRNA pseudouridine1911/1915/1917 synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. | RNA methyltransferase, TrmH family; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | 0.866 |