node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDB04784.1 | CDB05725.1 | BN691_01629 | BN691_00494 | Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | uDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.675 |
CDB04784.1 | guaA | BN691_01629 | BN691_01258 | Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | gMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 0.918 |
CDB04784.1 | guaB | BN691_01629 | BN691_00119 | Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.888 |
CDB04784.1 | murI | BN691_01629 | BN691_00587 | Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.919 |
CDB04784.1 | purL | BN691_01629 | BN691_00894 | Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Putative phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.409 |
CDB05722.1 | CDB05725.1 | BN691_00491 | BN691_00494 | Putative UDP-N-acetylmuramate--L-alanine ligase; Product inferred by homology to UniProt. | uDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.992 |
CDB05722.1 | CDB05853.1 | BN691_00491 | BN691_00621 | Putative UDP-N-acetylmuramate--L-alanine ligase; Product inferred by homology to UniProt. | Alanine racemase; Product inferred by homology to UniProt. | 0.939 |
CDB05722.1 | guaA | BN691_00491 | BN691_01258 | Putative UDP-N-acetylmuramate--L-alanine ligase; Product inferred by homology to UniProt. | gMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 0.438 |
CDB05722.1 | murE | BN691_00491 | BN691_00496 | Putative UDP-N-acetylmuramate--L-alanine ligase; Product inferred by homology to UniProt. | uDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.975 |
CDB05722.1 | murI | BN691_00491 | BN691_00587 | Putative UDP-N-acetylmuramate--L-alanine ligase; Product inferred by homology to UniProt. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.773 |
CDB05725.1 | CDB04784.1 | BN691_00494 | BN691_01629 | uDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.675 |
CDB05725.1 | CDB05722.1 | BN691_00494 | BN691_00491 | uDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | Putative UDP-N-acetylmuramate--L-alanine ligase; Product inferred by homology to UniProt. | 0.992 |
CDB05725.1 | CDB05853.1 | BN691_00494 | BN691_00621 | uDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | Alanine racemase; Product inferred by homology to UniProt. | 0.984 |
CDB05725.1 | glsA | BN691_00494 | BN691_01635 | uDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | Glutaminase; Product inferred by homology to UniProt; Belongs to the glutaminase family. | 0.568 |
CDB05725.1 | guaA | BN691_00494 | BN691_01258 | uDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | gMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 0.422 |
CDB05725.1 | murE | BN691_00494 | BN691_00496 | uDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | uDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.986 |
CDB05725.1 | murI | BN691_00494 | BN691_00587 | uDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.945 |
CDB05725.1 | purL | BN691_00494 | BN691_00894 | uDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | Putative phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.618 |
CDB05820.1 | murI | BN691_00588 | BN691_00587 | Outer membrane protein; Product inferred by homology to UniProt. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.605 |
CDB05853.1 | CDB05722.1 | BN691_00621 | BN691_00491 | Alanine racemase; Product inferred by homology to UniProt. | Putative UDP-N-acetylmuramate--L-alanine ligase; Product inferred by homology to UniProt. | 0.939 |