STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDD99899.16-O-methylguanine DNA methyltransferase DNA binding domain protein; Product inferred by homology to UniProt. (210 aa)    
Predicted Functional Partners:
CDE00987.1
Phosphoribosylformylglycinamidine synthase; Product inferred by homology to UniProt.
    
  0.906
CDE00279.1
Siroheme synthase; Product inferred by homology to UniProt.
  
  
 0.677
folD
Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.665
purD
Phosphoribosylamine--glycine ligase; Product inferred by homology to UniProt; Belongs to the GARS family.
  
  
  0.657
CDD99903.1
pAS domain S-box protein; Product inferred by homology to UniProt.
       0.654
polA
dNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
   
 
 0.632
queA
s-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
    
  0.627
CDD98821.1
Amino acid transporters/Alcohol dehydrogenase class IV; Product inferred by homology to UniProt.
 
   
 0.610
CDD99901.1
Putative uncharacterized protein; Product inferred by homology to UniProt.
       0.603
uvrB
uvrABC system protein B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and [...]
     
 0.574
Your Current Organism:
Roseburia sp. CAG471
NCBI taxonomy Id: 1262948
Other names: R. sp. CAG:471, Roseburia sp. CAG:471
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.