STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CCZ83862.15 10-methenyltetrahydrofolate synthetase; Product inferred by homology to UniProt; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (197 aa)    
Predicted Functional Partners:
folD
Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.919
purN
Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
    
 0.885
fhs
Formate--tetrahydrofolate ligase; Product inferred by homology to UniProt; Belongs to the formate--tetrahydrofolate ligase family.
   
 0.853
CCZ83863.1
dJ-1 family protein; Product inferred by homology to UniProt.
       0.809
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.668
CCZ84124.1
Glutamate synthase large subunit; Product inferred by homology to UniProt.
  
    0.638
CCZ83864.1
Putative uncharacterized protein; Product inferred by homology to UniProt.
       0.627
CCZ83865.1
Thymidylate kinase; Product inferred by homology to UniProt.
       0.627
thyX
Thymidylate synthase ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
       0.627
pheT
phenylalanine--tRNA ligase beta subunit; Product inferred by homology to UniProt; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
  
  
 0.611
Your Current Organism:
Ruminococcus sp. CAG254
NCBI taxonomy Id: 1262953
Other names: R. sp. CAG:254, Ruminococcus sp. CAG:254
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