node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDA71727.1 | fhs | BN718_00787 | BN718_02136 | Phosphoribosylformylglycinamidine synthase; Product inferred by homology to UniProt. | Formate--tetrahydrofolate ligase; Product inferred by homology to UniProt; Belongs to the formate--tetrahydrofolate ligase family. | 0.972 |
CDA71727.1 | fmt | BN718_00787 | BN718_01424 | Phosphoribosylformylglycinamidine synthase; Product inferred by homology to UniProt. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.934 |
CDA71727.1 | folD | BN718_00787 | BN718_00822 | Phosphoribosylformylglycinamidine synthase; Product inferred by homology to UniProt. | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.844 |
CDA71727.1 | glyA | BN718_00787 | BN718_00395 | Phosphoribosylformylglycinamidine synthase; Product inferred by homology to UniProt. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.981 |
CDA71727.1 | purN | BN718_00787 | BN718_01151 | Phosphoribosylformylglycinamidine synthase; Product inferred by homology to UniProt. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.998 |
CDA73277.1 | CDA73793.1 | BN718_01680 | BN718_01920 | folC bifunctional protein; Product inferred by homology to UniProt. | Homocysteine S-methyltransferase; Product inferred by homology to UniProt. | 0.931 |
CDA73277.1 | CDA74079.1 | BN718_01680 | BN718_02140 | folC bifunctional protein; Product inferred by homology to UniProt. | Ribose-5-phosphate isomerase B; Product inferred by homology to UniProt. | 0.538 |
CDA73277.1 | fhs | BN718_01680 | BN718_02136 | folC bifunctional protein; Product inferred by homology to UniProt. | Formate--tetrahydrofolate ligase; Product inferred by homology to UniProt; Belongs to the formate--tetrahydrofolate ligase family. | 0.952 |
CDA73277.1 | folD | BN718_01680 | BN718_00822 | folC bifunctional protein; Product inferred by homology to UniProt. | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.678 |
CDA73277.1 | glyA | BN718_01680 | BN718_00395 | folC bifunctional protein; Product inferred by homology to UniProt. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.949 |
CDA73793.1 | CDA73277.1 | BN718_01920 | BN718_01680 | Homocysteine S-methyltransferase; Product inferred by homology to UniProt. | folC bifunctional protein; Product inferred by homology to UniProt. | 0.931 |
CDA73793.1 | CDA73940.1 | BN718_01920 | BN718_02018 | Homocysteine S-methyltransferase; Product inferred by homology to UniProt. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.955 |
CDA73793.1 | CDA74079.1 | BN718_01920 | BN718_02140 | Homocysteine S-methyltransferase; Product inferred by homology to UniProt. | Ribose-5-phosphate isomerase B; Product inferred by homology to UniProt. | 0.916 |
CDA73793.1 | fhs | BN718_01920 | BN718_02136 | Homocysteine S-methyltransferase; Product inferred by homology to UniProt. | Formate--tetrahydrofolate ligase; Product inferred by homology to UniProt; Belongs to the formate--tetrahydrofolate ligase family. | 0.972 |
CDA73793.1 | fmt | BN718_01920 | BN718_01424 | Homocysteine S-methyltransferase; Product inferred by homology to UniProt. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.911 |
CDA73793.1 | folD | BN718_01920 | BN718_00822 | Homocysteine S-methyltransferase; Product inferred by homology to UniProt. | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.972 |
CDA73793.1 | glyA | BN718_01920 | BN718_00395 | Homocysteine S-methyltransferase; Product inferred by homology to UniProt. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.961 |
CDA73793.1 | purN | BN718_01920 | BN718_01151 | Homocysteine S-methyltransferase; Product inferred by homology to UniProt. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.896 |
CDA73793.1 | thyX | BN718_01920 | BN718_00911 | Homocysteine S-methyltransferase; Product inferred by homology to UniProt. | Thymidylate synthase ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.895 |
CDA73940.1 | CDA73793.1 | BN718_02018 | BN718_01920 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Homocysteine S-methyltransferase; Product inferred by homology to UniProt. | 0.955 |