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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDF08354.1Acetolactate synthase small subunit; Product inferred by homology to UniProt. (162 aa)    
Predicted Functional Partners:
CDF08353.1
Acetolactate synthase large subunit biosynthetic type; Product inferred by homology to UniProt.
 
 0.997
CDF07172.1
Acetolactate synthase; Product inferred by homology to UniProt.
 0.996
CDF07768.1
Thiamine pyrophosphate enzyme TPP binding domain protein; Product inferred by homology to UniProt; Belongs to the TPP enzyme family.
 0.991
CDF08385.1
Thiamine pyrophosphate protein domain protein TPP-binding; Product inferred by homology to UniProt; Belongs to the TPP enzyme family.
 0.989
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.984
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
  
 0.933
CDF06617.1
Homoserine dehydrogenase; Product inferred by homology to UniProt.
  
 
 0.912
CDF07078.1
Threonine dehydratase; Product inferred by homology to UniProt.
  
 
 0.906
leuD
3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.
  
 
 0.902
ilvD
Dihydroxy-acid dehydratase; Product inferred by homology to UniProt; Belongs to the IlvD/Edd family.
 
 0.888
Your Current Organism:
Firmicutes bacterium CAG95
NCBI taxonomy Id: 1262988
Other names: F. bacterium CAG:95, Firmicutes bacterium CAG:95
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