STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
clpBChaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (862 aa)    
Predicted Functional Partners:
clpP
aTP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
  
 
 0.980
CDF06595.1
Chaperone protein DnaK; Product inferred by homology to UniProt.
  
 
 0.979
CDF08324.1
Putative uncharacterized protein; Product inferred by homology to UniProt.
  
 
 0.976
CDF08663.1
Molecular chaperone; Product inferred by homology to UniProt; Belongs to the heat shock protein 70 family.
  
 
 0.976
CDF08834.1
Clp protease; Product inferred by homology to UniProt.
   
 
 0.976
CDF06500.1
Putative uncharacterized protein; Product inferred by homology to UniProt.
    
 
 0.939
CDF05955.1
Molecular chaperone (Small heat shock protein); Product inferred by homology to UniProt; Belongs to the small heat shock protein (HSP20) family.
 
 
 0.893
grpE
Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
  
 
 0.863
CDF06982.1
aTPase/histidine kinase/DNA gyrase B/HSP90 domain protein; Product inferred by homology to UniProt.
  
 
 0.849
groS
10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
  
 
 0.788
Your Current Organism:
Firmicutes bacterium CAG95
NCBI taxonomy Id: 1262988
Other names: F. bacterium CAG:95, Firmicutes bacterium CAG:95
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