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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDF05998.1Putative uncharacterized protein; Product inferred by homology to UniProt; Belongs to the folylpolyglutamate synthase family. (445 aa)    
Predicted Functional Partners:
CDF06004.1
Putative uncharacterized protein; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
 
 0.997
CDF06000.1
Putative uncharacterized protein; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
 
 0.996
CDF07878.1
Vitamin B12-dependent methionine synthase family protein; Product inferred by homology to UniProt.
   
 
 0.837
folD
Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
 
  
 0.770
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.753
fhs
Formate--tetrahydrofolate ligase; Product inferred by homology to UniProt; Belongs to the formate--tetrahydrofolate ligase family.
  
 
 0.728
CDF06327.1
Branched-chain amino acid aminotransferase; Product inferred by homology to UniProt.
    
 0.706
CDF07169.1
Putative uncharacterized protein; Product inferred by homology to UniProt; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
    
 0.697
CDF06325.1
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
     
 0.693
CDF06832.1
3-oxoacyl-(Acyl-carrier-protein) reductase; Product inferred by homology to UniProt; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  
 
  0.686
Your Current Organism:
Firmicutes bacterium CAG95
NCBI taxonomy Id: 1262988
Other names: F. bacterium CAG:95, Firmicutes bacterium CAG:95
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