STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lexAlexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (204 aa)    
Predicted Functional Partners:
recA
Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.976
CDC72758.1
dNA polymerase IV 2; Product inferred by homology to UniProt.
  
 0.726
CDC76524.1
uV-damage repair protein; Product inferred by homology to UniProt.
  
 0.726
CDC76960.1
dNA polymerase IV 2; Product inferred by homology to UniProt.
  
 0.726
dinB
dNA polymerase IV 2; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
  
 0.726
CDC72270.1
dNA polymerase III alpha subunit; Product inferred by homology to UniProt.
    
 0.673
CDC75808.1
Putative uncharacterized protein; Product inferred by homology to UniProt.
     
 0.574
CDC73037.1
Unknown; No significant homology to UniProt.
       0.561
CDC72208.1
dNA repair protein RecN; May be involved in recombinational repair of damaged DNA.
   
  
 0.537
CDC77105.1
Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain; Product inferred by homology to UniProt.
   
   0.530
Your Current Organism:
Firmicutes bacterium CAG272
NCBI taxonomy Id: 1263015
Other names: F. bacterium CAG:272, Firmicutes bacterium CAG:272
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.