LCOR_04047.1 protein (Lichtheimia corymbifera)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Coexpression

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[Homology]

Score

LCOR_04047.1

Acetyl-carboxylase. (2227 aa)

Predicted Functional Partners:

LCOR_09269.1

0.893

LCOR_07647.1

0.883

LCOR_04376.1

0.851

LCOR_01885.1

0.831

LCOR_07798.1

0.774

LCOR_05895.1

0.769

LCOR_02555.1

0.764

LCOR_04223.1

0.764

LCOR_03572.1

0.761

LCOR_06493.1

0.758

Your Current Organism:

Lichtheimia corymbifera

NCBI taxonomy Id: 1263082
Other names: L. corymbifera JMRC:FSU:9682, Lichtheimia corymbifera CBS 429.75, Lichtheimia corymbifera FSU 9682, Lichtheimia corymbifera JMRC:FSU:9682

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LCOR_01885.1	LCOR_03572.1	A0A068RJ17	A0A068RR08	Atp-citrate synthase subunit 1 (Atp-citrate (Pro-s-)-lyase 1).	Propionyl-beta subunit.	0.764
LCOR_01885.1	LCOR_04047.1	A0A068RJ17	A0A068RSB5	Atp-citrate synthase subunit 1 (Atp-citrate (Pro-s-)-lyase 1).	Acetyl-carboxylase.	0.831
LCOR_01885.1	LCOR_05895.1	A0A068RJ17	A0A068RWZ3	Atp-citrate synthase subunit 1 (Atp-citrate (Pro-s-)-lyase 1).	Aspartate-semialdehyde dehydrogenase.	0.769
LCOR_01885.1	LCOR_06493.1	A0A068RJ17	A0A068S013	Atp-citrate synthase subunit 1 (Atp-citrate (Pro-s-)-lyase 1).	Carboxyl transferase.	0.764
LCOR_01885.1	LCOR_07647.1	A0A068RJ17	A0A068S2Y2	Atp-citrate synthase subunit 1 (Atp-citrate (Pro-s-)-lyase 1).	3-oxoacyl-[acyl-carrier-protein] synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	0.529
LCOR_01885.1	LCOR_07798.1	A0A068RJ17	A0A068S6A0	Atp-citrate synthase subunit 1 (Atp-citrate (Pro-s-)-lyase 1).	3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.	0.784
LCOR_01885.1	LCOR_09269.1	A0A068RJ17	A0A068S7Q9	Atp-citrate synthase subunit 1 (Atp-citrate (Pro-s-)-lyase 1).	Fatty acid synthase beta subunit dehydratase.	0.792
LCOR_02555.1	LCOR_04047.1	A0A068RMB0	A0A068RSB5	Carbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family.	Acetyl-carboxylase.	0.764
LCOR_03572.1	LCOR_01885.1	A0A068RR08	A0A068RJ17	Propionyl-beta subunit.	Atp-citrate synthase subunit 1 (Atp-citrate (Pro-s-)-lyase 1).	0.764
LCOR_03572.1	LCOR_04047.1	A0A068RR08	A0A068RSB5	Propionyl-beta subunit.	Acetyl-carboxylase.	0.761
LCOR_03572.1	LCOR_04376.1	A0A068RR08	A0A068RVG7	Propionyl-beta subunit.	Malonyl-acyl carrier protein transacylase.	0.816
LCOR_03572.1	LCOR_05895.1	A0A068RR08	A0A068RWZ3	Propionyl-beta subunit.	Aspartate-semialdehyde dehydrogenase.	0.716
LCOR_03572.1	LCOR_06493.1	A0A068RR08	A0A068S013	Propionyl-beta subunit.	Carboxyl transferase.	0.752
LCOR_03572.1	LCOR_07647.1	A0A068RR08	A0A068S2Y2	Propionyl-beta subunit.	3-oxoacyl-[acyl-carrier-protein] synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	0.804
LCOR_04047.1	LCOR_01885.1	A0A068RSB5	A0A068RJ17	Acetyl-carboxylase.	Atp-citrate synthase subunit 1 (Atp-citrate (Pro-s-)-lyase 1).	0.831
LCOR_04047.1	LCOR_02555.1	A0A068RSB5	A0A068RMB0	Acetyl-carboxylase.	Carbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family.	0.764
LCOR_04047.1	LCOR_03572.1	A0A068RSB5	A0A068RR08	Acetyl-carboxylase.	Propionyl-beta subunit.	0.761
LCOR_04047.1	LCOR_04223.1	A0A068RSB5	A0A068RUY9	Acetyl-carboxylase.	Carbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family.	0.764
LCOR_04047.1	LCOR_04376.1	A0A068RSB5	A0A068RVG7	Acetyl-carboxylase.	Malonyl-acyl carrier protein transacylase.	0.851
LCOR_04047.1	LCOR_05895.1	A0A068RSB5	A0A068RWZ3	Acetyl-carboxylase.	Aspartate-semialdehyde dehydrogenase.	0.769

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Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.919

expected number of edges:

12

PPI enrichment p-value:

2.84e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0017148

Negative regulation of translation

7 of 38

2.15

4.88

1.05e-11

GO:0000288

Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

6 of 27

2.23

4.51

2.67e-10

GO:0006401

RNA catabolic process

9 of 96

1.86

4.33

9.40e-13

GO:0006402

mRNA catabolic process

8 of 76

1.91

4.27

7.63e-12

GO:0000956

Nuclear-transcribed mRNA catabolic process

7 of 71

1.88

3.75

3.17e-10

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004535

poly(A)-specific ribonuclease activity

3 of 4

2.76

2.23

8.28e-05

GO:0140098

Catalytic activity, acting on RNA

5 of 239

1.2

0.99

0.0016

GO:0003723

RNA binding

6 of 528

0.94

0.71

0.0035

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030015

CCR4-NOT core complex

6 of 6

2.88

6.45

6.98e-13

GO:0000932

P-body

6 of 29

2.2

4.39

4.04e-10

GO:0043232

Intracellular non-membrane-bounded organelle

7 of 988

0.73

0.52

0.0068

GO:0005634

Nucleus

9 of 2032

0.53

0.39

0.0078

GO:0032991

Protein-containing complex

8 of 1698

0.56

0.37

0.0188

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5685

CCR4-NOT core complex

5 of 5

2.88

5.31

1.20e-10

CL:5630

Mixed, incl. CCR4-NOT core complex, and RNA recognition motif

7 of 34

2.2

4.9

1.79e-11

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03018

RNA degradation

10 of 84

1.96

5.78

2.99e-17

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6804115

TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

5 of 7

2.74

4.93

4.71e-10

MAP-6791312

TP53 Regulates Transcription of Cell Cycle Genes

5 of 7

2.74

4.93

4.71e-10

MAP-429914

Deadenylation-dependent mRNA decay

7 of 41

2.12

4.62

3.65e-11

MAP-3700989

Transcriptional Regulation by TP53

5 of 149

1.41

1.46

0.00012

MAP-212436

Generic Transcription Pathway

6 of 230

1.3

1.44

3.40e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030014

CCR4-NOT complex

7 of 8

2.83

7.54

3.45e-15

GOCC:0030015

CCR4-NOT core complex

2 of 2

2.88

1.3

0.0045

GOCC:0032991

Protein-containing complex

9 of 2023

0.53

0.34

0.0298

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