LCOR_04315.1 protein (Lichtheimia corymbifera)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

LCOR_04315.1

F-box domain-containing protein. (597 aa)

Predicted Functional Partners:

LCOR_01731.1

0.812

LCOR_12310.1

0.812

LCOR_01828.1

0.808

LCOR_01611.1

0.800

LCOR_08912.1

0.800

LCOR_10533.1

0.744

LCOR_03778.1

0.728

LCOR_07745.1

0.728

LCOR_01765.1

0.720

LCOR_01789.1

0.711

Your Current Organism:

Lichtheimia corymbifera

NCBI taxonomy Id: 1263082
Other names: L. corymbifera JMRC:FSU:9682, Lichtheimia corymbifera CBS 429.75, Lichtheimia corymbifera FSU 9682, Lichtheimia corymbifera JMRC:FSU:9682

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LCOR_01611.1	LCOR_01731.1	A0A068RIQ5	A0A068RIN1	Cullin family protein; Belongs to the cullin family.	S-phase kinase-associated protein 1a-likeprotein; Belongs to the SKP1 family.	0.981
LCOR_01611.1	LCOR_01765.1	A0A068RIQ5	A0A068RIR7	Cullin family protein; Belongs to the cullin family.	Ubiquitin-40s ribosomal protein s31 fusionprotein.	0.875
LCOR_01611.1	LCOR_01789.1	A0A068RIQ5	A0A068RKC7	Cullin family protein; Belongs to the cullin family.	Elongation factor siii p15; Belongs to the SKP1 family.	0.890
LCOR_01611.1	LCOR_01828.1	A0A068RIQ5	A0A068RME1	Cullin family protein; Belongs to the cullin family.	Ring-box protein 1.	0.989
LCOR_01611.1	LCOR_03778.1	A0A068RIQ5	A0A068RUC5	Cullin family protein; Belongs to the cullin family.	Polyubiquitin.	0.894
LCOR_01611.1	LCOR_04315.1	A0A068RIQ5	A0A068RTE4	Cullin family protein; Belongs to the cullin family.	F-box domain-containing protein.	0.800
LCOR_01611.1	LCOR_07745.1	A0A068RIQ5	A0A068S648	Cullin family protein; Belongs to the cullin family.	Polyubiquitin.	0.894
LCOR_01611.1	LCOR_08912.1	A0A068RIQ5	A0A068S9W4	Cullin family protein; Belongs to the cullin family.	Cullin-domain-containing protein; Belongs to the cullin family.	0.454
LCOR_01611.1	LCOR_10533.1	A0A068RIQ5	A0A068SBG6	Cullin family protein; Belongs to the cullin family.	Nedd8.	0.980
LCOR_01611.1	LCOR_12310.1	A0A068RIQ5	A0A068SJ51	Cullin family protein; Belongs to the cullin family.	S-phase kinase-associated protein 1a-likeprotein; Belongs to the SKP1 family.	0.981
LCOR_01731.1	LCOR_01611.1	A0A068RIN1	A0A068RIQ5	S-phase kinase-associated protein 1a-likeprotein; Belongs to the SKP1 family.	Cullin family protein; Belongs to the cullin family.	0.981
LCOR_01731.1	LCOR_01765.1	A0A068RIN1	A0A068RIR7	S-phase kinase-associated protein 1a-likeprotein; Belongs to the SKP1 family.	Ubiquitin-40s ribosomal protein s31 fusionprotein.	0.873
LCOR_01731.1	LCOR_01789.1	A0A068RIN1	A0A068RKC7	S-phase kinase-associated protein 1a-likeprotein; Belongs to the SKP1 family.	Elongation factor siii p15; Belongs to the SKP1 family.	0.813
LCOR_01731.1	LCOR_01828.1	A0A068RIN1	A0A068RME1	S-phase kinase-associated protein 1a-likeprotein; Belongs to the SKP1 family.	Ring-box protein 1.	0.987
LCOR_01731.1	LCOR_03778.1	A0A068RIN1	A0A068RUC5	S-phase kinase-associated protein 1a-likeprotein; Belongs to the SKP1 family.	Polyubiquitin.	0.957
LCOR_01731.1	LCOR_04315.1	A0A068RIN1	A0A068RTE4	S-phase kinase-associated protein 1a-likeprotein; Belongs to the SKP1 family.	F-box domain-containing protein.	0.812
LCOR_01731.1	LCOR_07745.1	A0A068RIN1	A0A068S648	S-phase kinase-associated protein 1a-likeprotein; Belongs to the SKP1 family.	Polyubiquitin.	0.957
LCOR_01731.1	LCOR_08912.1	A0A068RIN1	A0A068S9W4	S-phase kinase-associated protein 1a-likeprotein; Belongs to the SKP1 family.	Cullin-domain-containing protein; Belongs to the cullin family.	0.965
LCOR_01731.1	LCOR_10533.1	A0A068RIN1	A0A068SBG6	S-phase kinase-associated protein 1a-likeprotein; Belongs to the SKP1 family.	Nedd8.	0.961
LCOR_01765.1	LCOR_01611.1	A0A068RIR7	A0A068RIQ5	Ubiquitin-40s ribosomal protein s31 fusionprotein.	Cullin family protein; Belongs to the cullin family.	0.875

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Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.925

expected number of edges:

12

PPI enrichment p-value:

3.47e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009073

Aromatic amino acid family biosynthetic process

9 of 10

2.5

8.01

1.26e-17

GO:0046417

Chorismate metabolic process

8 of 8

2.54

7.39

7.49e-16

GO:0009423

Chorismate biosynthetic process

7 of 7

2.54

6.39

1.43e-13

GO:0016053

Organic acid biosynthetic process

10 of 158

1.34

2.28

3.71e-11

GO:0008652

Cellular amino acid biosynthetic process

8 of 112

1.4

2.16

1.24e-08

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004764

Shikimate 3-dehydrogenase (NADP+) activity

2 of 2

2.54

0.83

0.0304

GO:0016838

Carbon-oxygen lyase activity, acting on phosphates

2 of 4

2.24

0.78

0.0371

GO:0016835

Carbon-oxygen lyase activity

3 of 32

1.51

0.7

0.0371

GO:0016829

Lyase activity

4 of 95

1.17

0.6

0.0371

GO:0003824

Catalytic activity

11 of 1844

0.32

0.24

0.0451

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:25072253

(2014) Identification of polyketide inhibitors targeting 3-dehydroquinate dehydratase in the shikimate pathway of Enterococcus faecalis.

3 of 3

2.54

1.55

0.0014

PMID:24586713

(2014) Discovery of selective inhibitors of the Clostridium difficile dehydroquinate dehydratase.

3 of 3

2.54

1.55

0.0014

PMID:35163582

(2022) Comparison of Automated Ribotyping, spa Typing, and MLST in 108 Clinical Isolates of Staphylococcus aureus from Orthopedic Infections.

3 of 4

2.42

1.54

0.0014

PMID:32391366

(2020) Prevalence, Characterization, and Drug Resistance of Staphylococcus Aureus in Feces From Pediatric Patients in Guangzhou, China.

3 of 5

2.32

1.52

0.0014

PMID:36873553

(2023) The effect of different C. difficile MLST strains on viability and activity of macrophages.

3 of 6

2.24

1.51

0.0014

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1319

Aromatic amino acid family biosynthetic process, and CorA, cytoplasmic domain

9 of 12

2.42

7.64

2.90e-17

CL:1322

Chorismate metabolic process

6 of 6

2.54

5.46

1.70e-11

CL:1291

Mixed, incl. Histidine biosynthetic process, and Aromatic amino acid family biosynthetic process

10 of 43

1.91

5.27

5.00e-16

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pdc00400

Phenylalanine, tyrosine and tryptophan biosynthesis

10 of 17

2.31

8.23

4.91e-20

pdc01230

Biosynthesis of amino acids

9 of 116

1.43

2.53

8.08e-11

pdc01110

Biosynthesis of secondary metabolites

10 of 235

1.17

1.71

3.28e-10

pdc01100

Metabolic pathways

11 of 605

0.8

0.85

4.23e-08

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0057

Aromatic amino acid biosynthesis

7 of 7

2.54

6.47

9.59e-14

KW-0521

NADP

3 of 23

1.66

1.19

0.0030

KW-0456

Lyase

4 of 92

1.18

0.85

0.0055

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08501

Shikimate dehydrogenase substrate binding domain

2 of 2

2.54

0.86

0.0274

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