LCOR_06134.1 protein (Lichtheimia corymbifera)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

LCOR_06134.1

Thioredoxin domain containing protein. (408 aa)

Predicted Functional Partners:

LCOR_09401.1

0.940

LCOR_01429.1

0.909

LCOR_02382.1

0.897

LCOR_07341.1

0.874

LCOR_10049.1

0.870

LCOR_01834.1

0.861

LCOR_01231.1

0.846

LCOR_11316.1

0.844

LCOR_02077.1

0.835

LCOR_02845.1

0.835

Your Current Organism:

Lichtheimia corymbifera

NCBI taxonomy Id: 1263082
Other names: L. corymbifera JMRC:FSU:9682, Lichtheimia corymbifera CBS 429.75, Lichtheimia corymbifera FSU 9682, Lichtheimia corymbifera JMRC:FSU:9682

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LCOR_01231.1	LCOR_01429.1	A0A068RHP4	A0A068RHN6	And tpr domain protein.	Endoplasmic oxidoreductin-1.	0.525
LCOR_01231.1	LCOR_01834.1	A0A068RHP4	A0A068RKG3	And tpr domain protein.	Thioredoxin-domain-containing protein.	0.846
LCOR_01231.1	LCOR_02382.1	A0A068RHP4	A0A068RNY6	And tpr domain protein.	Calreticulin.	0.535
LCOR_01231.1	LCOR_06134.1	A0A068RHP4	A0A068RZ84	And tpr domain protein.	Thioredoxin domain containing protein.	0.846
LCOR_01231.1	LCOR_09401.1	A0A068RHP4	A0A068S869	And tpr domain protein.	Protein disulfide-isomerase.	0.533
LCOR_01231.1	LCOR_11316.1	A0A068RHP4	A0A068SH58	And tpr domain protein.	Glucose-regulated protein; Belongs to the heat shock protein 70 family.	0.914
LCOR_01429.1	LCOR_01231.1	A0A068RHN6	A0A068RHP4	Endoplasmic oxidoreductin-1.	And tpr domain protein.	0.525
LCOR_01429.1	LCOR_01834.1	A0A068RHN6	A0A068RKG3	Endoplasmic oxidoreductin-1.	Thioredoxin-domain-containing protein.	0.927
LCOR_01429.1	LCOR_02382.1	A0A068RHN6	A0A068RNY6	Endoplasmic oxidoreductin-1.	Calreticulin.	0.432
LCOR_01429.1	LCOR_06134.1	A0A068RHN6	A0A068RZ84	Endoplasmic oxidoreductin-1.	Thioredoxin domain containing protein.	0.909
LCOR_01429.1	LCOR_09401.1	A0A068RHN6	A0A068S869	Endoplasmic oxidoreductin-1.	Protein disulfide-isomerase.	0.998
LCOR_01429.1	LCOR_11316.1	A0A068RHN6	A0A068SH58	Endoplasmic oxidoreductin-1.	Glucose-regulated protein; Belongs to the heat shock protein 70 family.	0.755
LCOR_01834.1	LCOR_01231.1	A0A068RKG3	A0A068RHP4	Thioredoxin-domain-containing protein.	And tpr domain protein.	0.846
LCOR_01834.1	LCOR_01429.1	A0A068RKG3	A0A068RHN6	Thioredoxin-domain-containing protein.	Endoplasmic oxidoreductin-1.	0.927
LCOR_01834.1	LCOR_02077.1	A0A068RKG3	A0A068RK31	Thioredoxin-domain-containing protein.	Peptide methionine sulfoxide reductase.	0.835
LCOR_01834.1	LCOR_02382.1	A0A068RKG3	A0A068RNY6	Thioredoxin-domain-containing protein.	Calreticulin.	0.897
LCOR_01834.1	LCOR_02845.1	A0A068RKG3	A0A068RLZ6	Thioredoxin-domain-containing protein.	Peptide methionine sulfoxide reductase.	0.835
LCOR_01834.1	LCOR_06134.1	A0A068RKG3	A0A068RZ84	Thioredoxin-domain-containing protein.	Thioredoxin domain containing protein.	0.861
LCOR_01834.1	LCOR_07341.1	A0A068RKG3	A0A068S1K9	Thioredoxin-domain-containing protein.	Uncharacterized protein.	0.874
LCOR_01834.1	LCOR_09401.1	A0A068RKG3	A0A068S869	Thioredoxin-domain-containing protein.	Protein disulfide-isomerase.	0.935

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.879

expected number of edges:

10

PPI enrichment p-value:

5.55e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045721

Negative regulation of gluconeogenesis

6 of 7

3.04

7.23

3.43e-14

GO:0043161

Proteasome-mediated ubiquitin-dependent protein catabolic process

10 of 144

1.95

5.44

6.43e-16

GO:0007039

Protein catabolic process in the vacuole

2 of 3

2.93

1.81

0.00053

GO:0072666

Establishment of protein localization to vacuole

2 of 31

1.92

0.87

0.0214

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0034657

GID complex

9 of 11

3.02

11.46

1.16e-22

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:18129

GID complex, and CRA domain

10 of 15

2.93

12.54

2.66e-25

CL:18126

Mixed, incl. GID complex, and Yip1 domain

11 of 28

2.7

12.22

2.90e-26

CL:18132

Negative regulation of gluconeogenesis, and Regulation of endocytosis

6 of 10

2.89

6.82

1.30e-13

CL:18136

Negative regulation of gluconeogenesis

4 of 5

3.01

4.4

8.09e-09

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3214815

HDACs deacetylate histones

5 of 12

2.73

4.89

5.64e-10

MAP-4839726

Chromatin organization

5 of 82

1.89

2.6

1.64e-06

MAP-3247509

Chromatin modifying enzymes

5 of 82

1.89

2.6

1.64e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0034657

GID complex

8 of 10

3.01

9.88

1.73e-19

GOCC:0032991

Protein-containing complex

11 of 2626

0.73

0.7

4.45e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0853

WD repeat

4 of 255

1.3

0.89

0.0071

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006595

CTLH, C-terminal LisH motif

4 of 5

3.01

3.91

6.82e-08

IPR024964

CTLH/CRA C-terminal to LisH motif domain

3 of 5

2.89

2.5

2.68e-05

IPR006594

LIS1 homology motif

3 of 9

2.63

2.25

7.00e-05

IPR045098

Fyv10 family

2 of 2

3.11

1.46

0.0023

IPR044063

Gid-type RING finger domain

2 of 2

3.11

1.46

0.0023

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00668

C-terminal to LisH motif.

3 of 4

2.98

2.97

3.84e-06

SM00667

Lissencephaly type-1-like homology motif

3 of 9

2.63

2.65

1.20e-05

SM00757

CT11-RanBPM

2 of 4

2.81

1.68

0.00086

SM00320

WD40 repeats

4 of 272

1.28

0.97

0.0033

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