LCOR_06956.1 protein (Lichtheimia corymbifera)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

LCOR_06956.1

Serine threonine-protein kinase afc3; Belongs to the protein kinase superfamily. (346 aa)

Predicted Functional Partners:

LCOR_02676.1

0.584

LCOR_05841.1

0.584

LCOR_09424.1

0.521

LCOR_02055.1

0.483

LCOR_00561.1

0.465

LCOR_07471.1

0.465

LCOR_02065.1

0.462

LCOR_07815.1

0.461

LCOR_08626.1

0.461

LCOR_06765.1

0.454

Your Current Organism:

Lichtheimia corymbifera

NCBI taxonomy Id: 1263082
Other names: L. corymbifera JMRC:FSU:9682, Lichtheimia corymbifera CBS 429.75, Lichtheimia corymbifera FSU 9682, Lichtheimia corymbifera JMRC:FSU:9682

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LCOR_00561.1	LCOR_02065.1	A0A068RGC9	A0A068RL37	Dwnn-domain-containing protein.	Pwi domain-containing protein.	0.435
LCOR_00561.1	LCOR_06956.1	A0A068RGC9	A0A068S1X7	Dwnn-domain-containing protein.	Serine threonine-protein kinase afc3; Belongs to the protein kinase superfamily.	0.465
LCOR_00561.1	LCOR_09424.1	A0A068RGC9	A0A068SBG7	Dwnn-domain-containing protein.	Transformer-2 protein homolog beta-like.	0.598
LCOR_02055.1	LCOR_06956.1	A0A068RMY2	A0A068S1X7	Geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C- terminal sequence -XXCC, -XCXC and -CCXX.	Serine threonine-protein kinase afc3; Belongs to the protein kinase superfamily.	0.483
LCOR_02065.1	LCOR_00561.1	A0A068RL37	A0A068RGC9	Pwi domain-containing protein.	Dwnn-domain-containing protein.	0.435
LCOR_02065.1	LCOR_02676.1	A0A068RL37	A0A068RM21	Pwi domain-containing protein.	Cmgc srpk protein kinase; Belongs to the protein kinase superfamily.	0.527
LCOR_02065.1	LCOR_05841.1	A0A068RL37	A0A068S067	Pwi domain-containing protein.	Serine protein kinase.	0.527
LCOR_02065.1	LCOR_06765.1	A0A068RL37	A0A068S0X4	Pwi domain-containing protein.	Uncharacterized protein.	0.761
LCOR_02065.1	LCOR_06956.1	A0A068RL37	A0A068S1X7	Pwi domain-containing protein.	Serine threonine-protein kinase afc3; Belongs to the protein kinase superfamily.	0.462
LCOR_02065.1	LCOR_07471.1	A0A068RL37	A0A068S2B4	Pwi domain-containing protein.	Smad fha domain-containing protein.	0.841
LCOR_02065.1	LCOR_09424.1	A0A068RL37	A0A068SBG7	Pwi domain-containing protein.	Transformer-2 protein homolog beta-like.	0.778
LCOR_02676.1	LCOR_02065.1	A0A068RM21	A0A068RL37	Cmgc srpk protein kinase; Belongs to the protein kinase superfamily.	Pwi domain-containing protein.	0.527
LCOR_02676.1	LCOR_06765.1	A0A068RM21	A0A068S0X4	Cmgc srpk protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.804
LCOR_02676.1	LCOR_06956.1	A0A068RM21	A0A068S1X7	Cmgc srpk protein kinase; Belongs to the protein kinase superfamily.	Serine threonine-protein kinase afc3; Belongs to the protein kinase superfamily.	0.584
LCOR_02676.1	LCOR_09424.1	A0A068RM21	A0A068SBG7	Cmgc srpk protein kinase; Belongs to the protein kinase superfamily.	Transformer-2 protein homolog beta-like.	0.440
LCOR_05841.1	LCOR_02065.1	A0A068S067	A0A068RL37	Serine protein kinase.	Pwi domain-containing protein.	0.527
LCOR_05841.1	LCOR_06765.1	A0A068S067	A0A068S0X4	Serine protein kinase.	Uncharacterized protein.	0.804
LCOR_05841.1	LCOR_06956.1	A0A068S067	A0A068S1X7	Serine protein kinase.	Serine threonine-protein kinase afc3; Belongs to the protein kinase superfamily.	0.584
LCOR_05841.1	LCOR_09424.1	A0A068S067	A0A068SBG7	Serine protein kinase.	Transformer-2 protein homolog beta-like.	0.440
LCOR_06765.1	LCOR_02065.1	A0A068S0X4	A0A068RL37	Uncharacterized protein.	Pwi domain-containing protein.	0.761

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Network Stats

number of nodes:

5

number of edges:

8

average node degree:

3.2

avg. local clustering coefficient:

0.867

expected number of edges:

4

PPI enrichment p-value:

0.0581

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006351

Transcription, DNA-templated

4 of 12

1.84

1.58

0.00052

GO:0034654

Nucleobase-containing compound biosynthetic process

5 of 121

0.93

0.5

0.0423

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003899

DNA-directed 5-3 RNA polymerase activity

4 of 6

2.14

2.25

3.45e-05

GO:0016779

Nucleotidyltransferase activity

5 of 69

1.17

0.99

0.0012

GO:0003677

DNA binding

7 of 182

0.9

0.75

0.00086

GO:0140640

Catalytic activity, acting on a nucleic acid

7 of 196

0.87

0.71

0.0011

GO:1901363

Heterocyclic compound binding

9 of 653

0.45

0.31

0.0306

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000428

DNA-directed RNA polymerase complex

4 of 7

2.07

2.42

1.14e-05

GO:0032991

Protein-containing complex

5 of 191

0.73

0.46

0.0229

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:289

RNA polymerase, and Nucleotide excision repair

6 of 7

2.25

4.17

2.06e-09

CL:97

Ribosome, and Protein export

8 of 105

1.2

1.48

1.07e-06

CL:618

Mixed, incl. WD40-repeat-containing domain superfamily, and ANK repeat

3 of 16

1.59

1.1

0.0044

CL:620

Mixed, incl. WD40-repeat-containing domain superfamily, and ANK repeat

2 of 7

1.77

0.77

0.0315

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03020

RNA polymerase

4 of 4

2.31

2.9

2.18e-06

map03420

Nucleotide excision repair

3 of 13

1.68

1.24

0.0024

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9635486

Infection with Mycobacterium tuberculosis

4 of 44

1.27

1.06

0.0014

MAP-5663205

Infectious disease

4 of 47

1.24

1.04

0.0014

MAP-1643685

Disease

4 of 52

1.2

1.0

0.0014

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031931

TORC1 complex

3 of 5

2.09

1.55

0.0010

GOCC:0000428

DNA-directed RNA polymerase complex

4 of 28

1.47

1.25

0.0010

GOCC:0032991

Protein-containing complex

8 of 367

0.65

0.51

0.0019

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0240

DNA-directed RNA polymerase

4 of 7

2.07

2.32

1.96e-05

KW-0548

Nucleotidyltransferase

5 of 36

1.46

1.58

6.43e-05

KW-0853

WD repeat

2 of 2

2.31

1.18

0.0064

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036322

WD40-repeat-containing domain superfamily

3 of 4

2.19

1.35

0.0028

IPR015943

WD40/YVTN repeat-like-containing domain superfamily

3 of 4

2.19

1.35

0.0028

IPR001680

WD40 repeat

2 of 2

2.31

0.76

0.0412

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00320

WD40 repeats

2 of 2

2.31

1.08

0.0102

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