LCOR_11425.1 protein (Lichtheimia corymbifera)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

LCOR_11425.1

Uncharacterized protein. (737 aa)

Predicted Functional Partners:

LCOR_03896.1

0.763

LCOR_09101.1

0.754

LCOR_10533.1

0.739

LCOR_10651.1

0.734

LCOR_03846.1

0.730

LCOR_10772.1

0.730

LCOR_04251.1

0.676

LCOR_09067.1

0.658

LCOR_08000.1

0.657

LCOR_11277.1

0.657

Your Current Organism:

Lichtheimia corymbifera

NCBI taxonomy Id: 1263082
Other names: L. corymbifera JMRC:FSU:9682, Lichtheimia corymbifera CBS 429.75, Lichtheimia corymbifera FSU 9682, Lichtheimia corymbifera JMRC:FSU:9682

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LCOR_03846.1	LCOR_04251.1	A0A068RTR0	A0A068RS20	Uncharacterized protein.	ANAPC4_WD40 domain-containing protein.	0.995
LCOR_03846.1	LCOR_09067.1	A0A068RTR0	A0A068S7D9	Uncharacterized protein.	Dead-domain-containing protein; Belongs to the DEAD box helicase family.	0.973
LCOR_03846.1	LCOR_10772.1	A0A068RTR0	A0A068SFC2	Uncharacterized protein.	Uncharacterized protein.	0.998
LCOR_03846.1	LCOR_11425.1	A0A068RTR0	A0A068SEE3	Uncharacterized protein.	Uncharacterized protein.	0.730
LCOR_03896.1	LCOR_09067.1	A0A068RS30	A0A068S7D9	Uncharacterized protein.	Dead-domain-containing protein; Belongs to the DEAD box helicase family.	0.663
LCOR_03896.1	LCOR_10533.1	A0A068RS30	A0A068SBG6	Uncharacterized protein.	Nedd8.	0.830
LCOR_03896.1	LCOR_11425.1	A0A068RS30	A0A068SEE3	Uncharacterized protein.	Uncharacterized protein.	0.763
LCOR_04251.1	LCOR_03846.1	A0A068RS20	A0A068RTR0	ANAPC4_WD40 domain-containing protein.	Uncharacterized protein.	0.995
LCOR_04251.1	LCOR_10772.1	A0A068RS20	A0A068SFC2	ANAPC4_WD40 domain-containing protein.	Uncharacterized protein.	0.995
LCOR_04251.1	LCOR_11425.1	A0A068RS20	A0A068SEE3	ANAPC4_WD40 domain-containing protein.	Uncharacterized protein.	0.676
LCOR_08000.1	LCOR_09101.1	A0A068S5B2	A0A068S7G9	40s ribosomal protein s22; Belongs to the universal ribosomal protein uS8 family.	Mrna export factor elf1.	0.989
LCOR_08000.1	LCOR_10533.1	A0A068S5B2	A0A068SBG6	40s ribosomal protein s22; Belongs to the universal ribosomal protein uS8 family.	Nedd8.	0.889
LCOR_08000.1	LCOR_11425.1	A0A068S5B2	A0A068SEE3	40s ribosomal protein s22; Belongs to the universal ribosomal protein uS8 family.	Uncharacterized protein.	0.657
LCOR_09067.1	LCOR_03846.1	A0A068S7D9	A0A068RTR0	Dead-domain-containing protein; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.973
LCOR_09067.1	LCOR_03896.1	A0A068S7D9	A0A068RS30	Dead-domain-containing protein; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.663
LCOR_09067.1	LCOR_09101.1	A0A068S7D9	A0A068S7G9	Dead-domain-containing protein; Belongs to the DEAD box helicase family.	Mrna export factor elf1.	0.631
LCOR_09067.1	LCOR_10772.1	A0A068S7D9	A0A068SFC2	Dead-domain-containing protein; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.973
LCOR_09067.1	LCOR_11425.1	A0A068S7D9	A0A068SEE3	Dead-domain-containing protein; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.658
LCOR_09101.1	LCOR_08000.1	A0A068S7G9	A0A068S5B2	Mrna export factor elf1.	40s ribosomal protein s22; Belongs to the universal ribosomal protein uS8 family.	0.989
LCOR_09101.1	LCOR_09067.1	A0A068S7G9	A0A068S7D9	Mrna export factor elf1.	Dead-domain-containing protein; Belongs to the DEAD box helicase family.	0.631

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

18

PPI enrichment p-value:

4.94e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035556

Intracellular signal transduction

6 of 251

1.49

1.72

2.45e-05

GO:0007165

Signal transduction

7 of 427

1.32

1.5

2.45e-05

GO:0010737

Protein kinase A signaling

2 of 4

2.81

1.38

0.0031

GO:0006796

Phosphate-containing compound metabolic process

6 of 765

1.0

0.77

0.0032

GO:0048519

Negative regulation of biological process

5 of 541

1.07

0.73

0.0090

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004690

Cyclic nucleotide-dependent protein kinase activity

4 of 5

3.01

4.05

3.74e-08

GO:0004679

AMP-activated protein kinase activity

3 of 3

3.11

2.91

5.24e-06

GO:0004691

cAMP-dependent protein kinase activity

3 of 4

2.98

2.86

6.11e-06

GO:0019003

GDP binding

2 of 3

2.93

1.48

0.0021

GO:0016772

Transferase activity, transferring phosphorus-containing groups

5 of 544

1.07

0.79

0.0045

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005952

cAMP-dependent protein kinase complex

2 of 4

2.81

1.21

0.0064

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3280

Mixed, incl. Cyclic nucleotide-dependent protein kinase activity, and AKT phosphorylates targets in the nucleus

5 of 16

2.6

4.43

3.23e-09

CL:3208

Mixed, incl. Peptidyl-serine phosphorylation, and Aquaporin-mediated transport

6 of 52

2.17

3.99

3.23e-09

CL:3282

Mixed, incl. Cyclic nucleotide-dependent protein kinase activity, and AKT phosphorylates targets in the nucleus

4 of 11

2.67

3.66

1.31e-07

CL:3285

G protein activity, and Cyclic nucleotide-dependent protein kinase activity

3 of 5

2.89

2.8

7.61e-06

CL:2922

Protein kinase domain, and GTPase regulator activity

7 of 196

1.66

2.76

2.32e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04113

Meiosis - yeast

4 of 131

1.59

1.5

0.00035

map04138

Autophagy - yeast

3 of 150

1.41

0.84

0.0135

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9634597

GPER1 signaling

3 of 4

2.98

2.88

5.70e-06

MAP-442720

CREB1 phosphorylation through the activation of Adenylate Cyclase

3 of 4

2.98

2.88

5.70e-06

MAP-164378

PKA activation in glucagon signalling

3 of 4

2.98

2.88

5.70e-06

MAP-163615

PKA activation

3 of 4

2.98

2.88

5.70e-06

MAP-163359

Glucagon signaling in metabolic regulation

3 of 4

2.98

2.88

5.70e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005952

cAMP-dependent protein kinase complex

3 of 5

2.89

2.59

1.86e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR020849

Small GTPase, Ras-type

2 of 4

2.81

0.91

0.0225

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00173

Ras subfamily of RAS small GTPases

2 of 3

2.93

1.53

0.0017

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