node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FEN1 | LCOR_01075.1 | A0A068RHE1 | A0A068RGM3 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Dna mismatch repair protein msh6; Component of the post-replicative DNA mismatch repair system (MMR). | 0.931 |
FEN1 | LCOR_02111.1 | A0A068RHE1 | A0A068RK59 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 3'-5' exonuclease domain-containing protein. | 0.998 |
FEN1 | LCOR_03924.1 | A0A068RHE1 | A0A068RS58 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Activator 1 37 kDa subunit. | 0.953 |
FEN1 | LCOR_05293.1 | A0A068RHE1 | A0A068RWC4 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | E3 ubiquitin-protein ligase rad18. | 0.532 |
FEN1 | LCOR_05514.1 | A0A068RHE1 | A0A068RWY3 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Replication factor c subunit 2. | 0.959 |
FEN1 | LCOR_06584.1 | A0A068RHE1 | A0A068S0Q9 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA polymerase. | 0.993 |
FEN1 | LCOR_07791.1 | A0A068RHE1 | A0A068S3C4 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | P-loop containing nucleoside triphosphatehydrolase protein. | 0.891 |
FEN1 | LCOR_07924.1 | A0A068RHE1 | A0A068S501 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Replication factor C subunit 1. | 0.927 |
FEN1 | LCOR_08697.1 | A0A068RHE1 | A0A068S5Z4 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Dna polymerase small subunit. | 0.982 |
FEN1 | LCOR_10571.1 | A0A068RHE1 | A0A068SES6 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Vezatin domain-containing protein. | 0.994 |
LCOR_01075.1 | FEN1 | A0A068RGM3 | A0A068RHE1 | Dna mismatch repair protein msh6; Component of the post-replicative DNA mismatch repair system (MMR). | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.931 |
LCOR_01075.1 | LCOR_02111.1 | A0A068RGM3 | A0A068RK59 | Dna mismatch repair protein msh6; Component of the post-replicative DNA mismatch repair system (MMR). | 3'-5' exonuclease domain-containing protein. | 0.858 |
LCOR_01075.1 | LCOR_03924.1 | A0A068RGM3 | A0A068RS58 | Dna mismatch repair protein msh6; Component of the post-replicative DNA mismatch repair system (MMR). | Activator 1 37 kDa subunit. | 0.565 |
LCOR_01075.1 | LCOR_05514.1 | A0A068RGM3 | A0A068RWY3 | Dna mismatch repair protein msh6; Component of the post-replicative DNA mismatch repair system (MMR). | Replication factor c subunit 2. | 0.656 |
LCOR_01075.1 | LCOR_06584.1 | A0A068RGM3 | A0A068S0Q9 | Dna mismatch repair protein msh6; Component of the post-replicative DNA mismatch repair system (MMR). | DNA polymerase. | 0.931 |
LCOR_01075.1 | LCOR_07791.1 | A0A068RGM3 | A0A068S3C4 | Dna mismatch repair protein msh6; Component of the post-replicative DNA mismatch repair system (MMR). | P-loop containing nucleoside triphosphatehydrolase protein. | 0.406 |
LCOR_01075.1 | LCOR_07924.1 | A0A068RGM3 | A0A068S501 | Dna mismatch repair protein msh6; Component of the post-replicative DNA mismatch repair system (MMR). | Replication factor C subunit 1. | 0.630 |
LCOR_01075.1 | LCOR_10571.1 | A0A068RGM3 | A0A068SES6 | Dna mismatch repair protein msh6; Component of the post-replicative DNA mismatch repair system (MMR). | Vezatin domain-containing protein. | 0.987 |
LCOR_02111.1 | FEN1 | A0A068RK59 | A0A068RHE1 | 3'-5' exonuclease domain-containing protein. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.998 |
LCOR_02111.1 | LCOR_01075.1 | A0A068RK59 | A0A068RGM3 | 3'-5' exonuclease domain-containing protein. | Dna mismatch repair protein msh6; Component of the post-replicative DNA mismatch repair system (MMR). | 0.858 |