node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KGE03556.1 | KGE03632.1 | HRUBRA_01935 | HRUBRA_01723 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homoserine dehydrogenase. | 0.966 |
KGE03556.1 | KGE03886.1 | HRUBRA_01935 | HRUBRA_01503 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Phosphoserine phosphatase. | 0.756 |
KGE03556.1 | KGE03993.1 | HRUBRA_01935 | HRUBRA_01399 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Serine acetyltransferase. | 0.751 |
KGE03556.1 | KGE05253.1 | HRUBRA_01935 | HRUBRA_00126 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cysteine synthase B; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.838 |
KGE03556.1 | cysS | HRUBRA_01935 | HRUBRA_02626 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.801 |
KGE03556.1 | glyA | HRUBRA_01935 | HRUBRA_01185 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.921 |
KGE03632.1 | KGE03556.1 | HRUBRA_01723 | HRUBRA_01935 | Homoserine dehydrogenase. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.966 |
KGE03632.1 | KGE03886.1 | HRUBRA_01723 | HRUBRA_01503 | Homoserine dehydrogenase. | Phosphoserine phosphatase. | 0.931 |
KGE03632.1 | KGE03993.1 | HRUBRA_01723 | HRUBRA_01399 | Homoserine dehydrogenase. | Serine acetyltransferase. | 0.774 |
KGE03632.1 | KGE05112.1 | HRUBRA_01723 | HRUBRA_00314 | Homoserine dehydrogenase. | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.752 |
KGE03632.1 | KGE05253.1 | HRUBRA_01723 | HRUBRA_00126 | Homoserine dehydrogenase. | Cysteine synthase B; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.718 |
KGE03632.1 | cysS | HRUBRA_01723 | HRUBRA_02626 | Homoserine dehydrogenase. | Cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.471 |
KGE03632.1 | glyA | HRUBRA_01723 | HRUBRA_01185 | Homoserine dehydrogenase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.773 |
KGE03632.1 | trpA | HRUBRA_01723 | HRUBRA_01172 | Homoserine dehydrogenase. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.771 |
KGE03632.1 | trpB | HRUBRA_01723 | HRUBRA_01171 | Homoserine dehydrogenase. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.727 |
KGE03886.1 | KGE03556.1 | HRUBRA_01503 | HRUBRA_01935 | Phosphoserine phosphatase. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.756 |
KGE03886.1 | KGE03632.1 | HRUBRA_01503 | HRUBRA_01723 | Phosphoserine phosphatase. | Homoserine dehydrogenase. | 0.931 |
KGE03886.1 | KGE03993.1 | HRUBRA_01503 | HRUBRA_01399 | Phosphoserine phosphatase. | Serine acetyltransferase. | 0.957 |
KGE03886.1 | KGE04129.1 | HRUBRA_01503 | HRUBRA_01261 | Phosphoserine phosphatase. | CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.886 |
KGE03886.1 | KGE05112.1 | HRUBRA_01503 | HRUBRA_00314 | Phosphoserine phosphatase. | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.918 |