STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CCQ91076.1Putative Mg-protoporphyrin IX monomethyl ester oxidative cyclase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (592 aa)    
Predicted Functional Partners:
mutM
Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
       0.773
CCQ89775.1
Hypothetical protein, putative Cobalamin-binding Fe-S oxidoreductase; No homology to any previously reported sequences.
  
     0.733
grpE
Putative Protein grpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-de [...]
       0.727
CCQ91484.1
Hypothetical protein; No homology to any previously reported sequences.
 
 
  0.599
ilvD
Dihydroxy-acid dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the IlvD/Edd family.
       0.527
CCQ90255.1
Putative Cytochrome c oxidase, fused subunits I, II, and III (modular protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
   
    0.480
CCQ90481.1
Conserved hypothetical protein, putative radical SAM; Homologs of previously reported genes of unknown function; 14633981, 14704425, 15317939.
  
     0.437
CCQ91276.1
Conserved hypothetical protein, putative radical SAM with vitamin B12-binding domain; Homologs of previously reported genes of unknown function.
  
     0.425
CCQ90727.1
Putative Radical SAM/B12 binding domain protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.
  
     0.408
Your Current Organism:
Nitrospina gracilis
NCBI taxonomy Id: 1266370
Other names: N. gracilis 3/211, Nitrospina gracilis 3/211, Nitrospina gracilis str. 3/211, Nitrospina gracilis strain 3/211
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