Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (331 aa)    
Predicted Functional Partners:
bioD
Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.
 
 
 0.998
bioA
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
  
 0.996
BioF
8-amino-7-oxononanoate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.981
ORV42035.1
biotin--acetyl-CoA-carboxylase ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.974
ORV44989.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.950
ORV44924.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.889
nadE
NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
     
 0.700
ORV44922.1
TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.676
thiC
Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
 
  
 0.588
AWC01_01715
MerR family transcriptional regulator; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.576
Your Current Organism:
Mycolicibacterium doricum
NCBI taxonomy Id: 126673
Other names: CCUG 46352, CIP 106867, DSM 44339, JCM 12405, M. doricum, Mycobacterium doricum, Mycobacterium doricum Tortoli et al. 2001, Mycolicibacterium doricum (Tortoli et al., 2001) Gupta et al. 2018, strain FI-13295
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