STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BV394_10595SH3 domain-containing protein. (167 aa)    
Predicted Functional Partners:
guaA
GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.
    
  0.818
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
    
  0.816
BV394_05700
SPOR domain-containing protein.
  
  
  0.521
BV394_09295
D-arabinose 5-phosphate; Belongs to the SIS family. GutQ/KpsF subfamily.
    
  0.494
BV394_08990
dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
    
  0.493
pyrF
Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
    
  0.492
BV394_10590
Short-subunit dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  
    0.479
BV394_14055
MurNAc-LAA domain-containing protein.
    
  0.474
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
     
 0.467
cmk
Cytidylate kinase.
    
  0.465
Your Current Organism:
Brevirhabdus pacifica
NCBI taxonomy Id: 1267768
Other names: B. pacifica, Brevirhabdus pacifica Wu et al. 2015 emend. Liu et al. 2017, CGMCC 1.12416, DSM 27767, JCM 19489, KCTC 42421 [[Xuhuaishuia manganoxidans]], Loktanella sp. 22DY15, MCCC 1K00276, MCCC 1K00502 [[Xuhuaishuia manganoxidans]], Roseovarius sp. DY6-4, Xuhuaishuia manganoxidans, Xuhuaishuia manganoxidans Wang et al. 2016, strain 22DY15, strain DY6-4 [[Xuhuaishuia manganoxidans]]
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