node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MCM7 | PVX_079890 | A5KA60 | A5K987 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | DNA replication licensing factor MCM3, putative; Belongs to the MCM family. | 0.999 |
MCM7 | PVX_084195 | A5KA60 | A5K0D2 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | 0.994 |
MCM7 | PVX_084615 | A5KA60 | A5K0L6 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | DNA replication licensing factor MCM5, putative; Belongs to the MCM family. | 0.999 |
MCM7 | PVX_085565 | A5KA60 | A5K152 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | DNA helicase. | 0.994 |
MCM7 | PVX_087805 | A5KA60 | A5KA59 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Uncharacterized protein. | 0.999 |
MCM7 | PVX_097665 | A5KA60 | A5KAU9 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | AAA domain-containing protein. | 0.999 |
MCM7 | PVX_114615 | A5KA60 | A5K2D4 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | DNA polymerase epsilon, catalytic subunit a, putative. | 0.988 |
MCM7 | PVX_114735 | A5KA60 | A5K2F8 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | DNA helicase; Belongs to the MCM family. | 0.999 |
MCM7 | PVX_122085 | A5KA60 | A5JZ42 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Mcl1_mid domain-containing protein. | 0.992 |
MCM7 | PVX_122675 | A5KA60 | A5JZG0 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | DNA replication licensing factor MCM4, putative; Belongs to the MCM family. | 0.999 |
PVX_079890 | MCM7 | A5K987 | A5KA60 | DNA replication licensing factor MCM3, putative; Belongs to the MCM family. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.999 |
PVX_079890 | PVX_084195 | A5K987 | A5K0D2 | DNA replication licensing factor MCM3, putative; Belongs to the MCM family. | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | 0.997 |
PVX_079890 | PVX_084615 | A5K987 | A5K0L6 | DNA replication licensing factor MCM3, putative; Belongs to the MCM family. | DNA replication licensing factor MCM5, putative; Belongs to the MCM family. | 0.999 |
PVX_079890 | PVX_085565 | A5K987 | A5K152 | DNA replication licensing factor MCM3, putative; Belongs to the MCM family. | DNA helicase. | 0.995 |
PVX_079890 | PVX_087805 | A5K987 | A5KA59 | DNA replication licensing factor MCM3, putative; Belongs to the MCM family. | Uncharacterized protein. | 0.999 |
PVX_079890 | PVX_097665 | A5K987 | A5KAU9 | DNA replication licensing factor MCM3, putative; Belongs to the MCM family. | AAA domain-containing protein. | 0.999 |
PVX_079890 | PVX_114615 | A5K987 | A5K2D4 | DNA replication licensing factor MCM3, putative; Belongs to the MCM family. | DNA polymerase epsilon, catalytic subunit a, putative. | 0.996 |
PVX_079890 | PVX_114735 | A5K987 | A5K2F8 | DNA replication licensing factor MCM3, putative; Belongs to the MCM family. | DNA helicase; Belongs to the MCM family. | 0.995 |
PVX_079890 | PVX_122085 | A5K987 | A5JZ42 | DNA replication licensing factor MCM3, putative; Belongs to the MCM family. | Mcl1_mid domain-containing protein. | 0.997 |
PVX_079890 | PVX_122675 | A5K987 | A5JZG0 | DNA replication licensing factor MCM3, putative; Belongs to the MCM family. | DNA replication licensing factor MCM4, putative; Belongs to the MCM family. | 0.999 |