T1ISC2_STRMM protein (Strigamia maritima) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

T1ISC2_STRMM

Peptidase_S8 domain-containing protein. (1058 aa)

Predicted Functional Partners:

T1IP50_STRMM

0.768

T1J3N1_STRMM

0.768

T1J5K9_STRMM

0.768

T1JK83_STRMM

0.768

T1IXP9_STRMM

0.722

T1JCH3_STRMM

0.713

T1JFR1_STRMM

0.695

T1JLK8_STRMM

0.679

T1JIE9_STRMM

0.645

T1JJD1_STRMM

0.616

Your Current Organism:

Strigamia maritima

NCBI taxonomy Id: 126957
Other names: S. maritima

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T1IP50_STRMM	T1ISC2_STRMM	T1IP50	T1ISC2	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Peptidase_S8 domain-containing protein.	0.768
T1IP50_STRMM	T1J3N1_STRMM	T1IP50	T1J3N1	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Uncharacterized protein.	0.675
T1IP50_STRMM	T1J5K9_STRMM	T1IP50	T1J5K9	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Uncharacterized protein.	0.675
T1IP50_STRMM	T1JK83_STRMM	T1IP50	T1JK83	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Uncharacterized protein.	0.675
T1ISC2_STRMM	T1IP50_STRMM	T1ISC2	T1IP50	Peptidase_S8 domain-containing protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.768
T1ISC2_STRMM	T1IXP9_STRMM	T1ISC2	T1IXP9	Peptidase_S8 domain-containing protein.	BZIP domain-containing protein.	0.722
T1ISC2_STRMM	T1J3N1_STRMM	T1ISC2	T1J3N1	Peptidase_S8 domain-containing protein.	Uncharacterized protein.	0.768
T1ISC2_STRMM	T1J5K9_STRMM	T1ISC2	T1J5K9	Peptidase_S8 domain-containing protein.	Uncharacterized protein.	0.768
T1ISC2_STRMM	T1JCH3_STRMM	T1ISC2	T1JCH3	Peptidase_S8 domain-containing protein.	BHLH domain-containing protein.	0.713
T1ISC2_STRMM	T1JFR1_STRMM	T1ISC2	T1JFR1	Peptidase_S8 domain-containing protein.	BZIP domain-containing protein.	0.695
T1ISC2_STRMM	T1JIE9_STRMM	T1ISC2	T1JIE9	Peptidase_S8 domain-containing protein.	Uncharacterized protein.	0.645
T1ISC2_STRMM	T1JJD1_STRMM	T1ISC2	T1JJD1	Peptidase_S8 domain-containing protein.	Fam20C domain-containing protein.	0.616
T1ISC2_STRMM	T1JK83_STRMM	T1ISC2	T1JK83	Peptidase_S8 domain-containing protein.	Uncharacterized protein.	0.768
T1ISC2_STRMM	T1JLK8_STRMM	T1ISC2	T1JLK8	Peptidase_S8 domain-containing protein.	BZIP domain-containing protein.	0.679
T1IXP9_STRMM	T1ISC2_STRMM	T1IXP9	T1ISC2	BZIP domain-containing protein.	Peptidase_S8 domain-containing protein.	0.722
T1IXP9_STRMM	T1JCH3_STRMM	T1IXP9	T1JCH3	BZIP domain-containing protein.	BHLH domain-containing protein.	0.509
T1IXP9_STRMM	T1JFR1_STRMM	T1IXP9	T1JFR1	BZIP domain-containing protein.	BZIP domain-containing protein.	0.872
T1IXP9_STRMM	T1JIE9_STRMM	T1IXP9	T1JIE9	BZIP domain-containing protein.	Uncharacterized protein.	0.811
T1IXP9_STRMM	T1JLK8_STRMM	T1IXP9	T1JLK8	BZIP domain-containing protein.	BZIP domain-containing protein.	0.888
T1J3N1_STRMM	T1IP50_STRMM	T1J3N1	T1IP50	Uncharacterized protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.675

page 1 of 3

Network Stats

number of nodes:

4

number of edges:

3

average node degree:

1.5

avg. local clustering coefficient:

0.75

expected number of edges:

3

PPI enrichment p-value:

0.562

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045664

Regulation of neuron differentiation

6 of 80

2.19

3.85

8.75e-09

GO:0045666

Positive regulation of neuron differentiation

5 of 40

2.41

3.76

4.36e-08

GO:0001711

Endodermal cell fate commitment

2 of 3

3.14

1.83

0.00049

GO:0045597

Positive regulation of cell differentiation

6 of 478

1.42

1.69

1.34e-05

GO:0045944

Positive regulation of transcription by RNA polymerase II

8 of 880

1.28

1.66

7.57e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070888

E-box binding

7 of 32

2.66

6.95

2.09e-14

GO:0008134

Transcription factor binding

7 of 358

1.61

2.49

1.04e-07

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

6 of 252

1.69

2.43

7.66e-07

GO:0046982

Protein heterodimerization activity

6 of 258

1.68

2.41

7.66e-07

GO:0046983

Protein dimerization activity

7 of 842

1.24

1.42

1.23e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005667

Transcription regulator complex

7 of 371

1.59

2.44

1.25e-07

GO:0016593

Cdc73/Paf1 complex

2 of 9

2.66

1.27

0.0048

GO:0005721

Pericentric heterochromatin

2 of 18

2.36

1.03

0.0125

GO:0005634

Nucleus

11 of 6688

0.53

0.43

0.00085

GO:0032991

Protein-containing complex

9 of 5100

0.56

0.39

0.0125

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36459298

(2022) Achiasmatic meiosis in the unisexual Amazon molly, Poecilia formosa.

2 of 20

2.32

0.77

0.0397

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:31959

Myogenesis, and DNA-binding protein inhibitor

6 of 24

2.72

5.82

6.88e-12

CL:31867

Mixed, incl. Helix-loop-helix DNA-binding domain superfamily, and RUNX1 regulates transcription of genes involved in differentiation of HSCs

7 of 114

2.11

4.48

7.89e-11

CL:31960

MADS MEF2-like, and Myogenic factor

3 of 15

2.62

2.36

4.20e-05

CL:10560

Endodermal cell fate commitment, and Spinal cord oligodendrocyte cell differentiation

2 of 5

2.92

1.45

0.0024

CL:31990

DNA-binding protein inhibitor, and Positive regulation of skeletal muscle fiber development

2 of 6

2.84

1.4

0.0029

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-525793

Myogenesis

5 of 54

2.28

3.55

7.30e-08

MAP-1266738

Developmental Biology

6 of 811

1.19

1.06

0.00067

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016593

Cdc73/Paf1 complex

2 of 8

2.72

1.23

0.0058

GOCC:0005721

Pericentric heterochromatin

2 of 7

2.77

1.23

0.0058

GOCC:0005634

Nucleus

9 of 3523

0.72

0.55

0.0031

GOCC:0043229

Intracellular organelle

11 of 9083

0.4

0.3

0.0150

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036638

Helix-loop-helix DNA-binding domain superfamily

5 of 144

1.86

2.07

3.49e-05

IPR011598

Myc-type, basic helix-loop-helix (bHLH) domain

5 of 145

1.86

2.07

3.49e-05

IPR008251

Chromo shadow domain

2 of 5

2.92

1.1

0.0104

IPR017984

Chromo domain subgroup

2 of 10

2.62

0.89

0.0246

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00353

Helix loop helix domain

5 of 149

1.84

2.38

4.51e-06

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (30%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About