T1JDK2_STRMM protein (Strigamia maritima) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

T1JDK2_STRMM

Uncharacterized protein. (993 aa)

Predicted Functional Partners:

T1ITH1_STRMM

0.939

T1IUF7_STRMM

0.929

T1J1M0_STRMM

0.898

T1INI5_STRMM

0.884

T1IZC7_STRMM

0.869

T1IHK3_STRMM

0.857

T1IY72_STRMM

0.842

T1JL53_STRMM

0.836

T1IV53_STRMM

0.835

T1J3C0_STRMM

0.815

Your Current Organism:

Strigamia maritima

NCBI taxonomy Id: 126957
Other names: S. maritima

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T1IHK3_STRMM	T1JDK2_STRMM	T1IHK3	T1JDK2	SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	Uncharacterized protein.	0.857
T1INI5_STRMM	T1ITH1_STRMM	T1INI5	T1ITH1	Protein kinase domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.452
T1INI5_STRMM	T1IUF7_STRMM	T1INI5	T1IUF7	Protein kinase domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.451
T1INI5_STRMM	T1IV53_STRMM	T1INI5	T1IV53	Protein kinase domain-containing protein.	TPR_REGION domain-containing protein.	0.608
T1INI5_STRMM	T1JDK2_STRMM	T1INI5	T1JDK2	Protein kinase domain-containing protein.	Uncharacterized protein.	0.884
T1ITH1_STRMM	T1INI5_STRMM	T1ITH1	T1INI5	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.452
T1ITH1_STRMM	T1IUF7_STRMM	T1ITH1	T1IUF7	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.843
T1ITH1_STRMM	T1IY72_STRMM	T1ITH1	T1IY72	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.912
T1ITH1_STRMM	T1J3C0_STRMM	T1ITH1	T1J3C0	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.993
T1ITH1_STRMM	T1JDK2_STRMM	T1ITH1	T1JDK2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.939
T1ITH1_STRMM	T1JL53_STRMM	T1ITH1	T1JL53	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.871
T1IUF7_STRMM	T1INI5_STRMM	T1IUF7	T1INI5	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.451
T1IUF7_STRMM	T1ITH1_STRMM	T1IUF7	T1ITH1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.843
T1IUF7_STRMM	T1J1M0_STRMM	T1IUF7	T1J1M0	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Thioredoxin; Belongs to the thioredoxin family.	0.655
T1IUF7_STRMM	T1J3C0_STRMM	T1IUF7	T1J3C0	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.869
T1IUF7_STRMM	T1JDK2_STRMM	T1IUF7	T1JDK2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.929
T1IUF7_STRMM	T1JL53_STRMM	T1IUF7	T1JL53	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.630
T1IV53_STRMM	T1INI5_STRMM	T1IV53	T1INI5	TPR_REGION domain-containing protein.	Protein kinase domain-containing protein.	0.608
T1IV53_STRMM	T1JDK2_STRMM	T1IV53	T1JDK2	TPR_REGION domain-containing protein.	Uncharacterized protein.	0.835
T1IV53_STRMM	T1JL53_STRMM	T1IV53	T1JL53	TPR_REGION domain-containing protein.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.635

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Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

24

PPI enrichment p-value:

1.44e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006364

rRNA processing

9 of 197

1.18

1.47

7.40e-07

GO:0016070

RNA metabolic process

11 of 699

0.72

0.67

8.59e-06

GO:0010467

Gene expression

11 of 942

0.59

0.51

0.00012

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030515

snoRNA binding

4 of 35

1.58

1.13

0.0036

GO:0003676

Nucleic acid binding

10 of 839

0.6

0.45

0.0036

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030686

90S preribosome

5 of 36

1.66

2.02

1.30e-05

GO:0030684

Preribosome

7 of 90

1.41

1.93

6.45e-07

GO:0032040

Small-subunit processome

5 of 43

1.58

1.91

1.47e-05

GO:0005730

Nucleolus

11 of 263

1.14

1.63

3.01e-10

GO:0070545

PeBoW complex

2 of 3

2.34

1.19

0.0063

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2532

Preribosome, and ATP-dependent RNA helicase DEAD-box, conserved site

9 of 96

1.49

2.64

3.65e-10

CL:2635

Preribosome, large subunit precursor, and Ribosomal large subunit biogenesis

5 of 43

1.58

1.97

9.11e-06

CL:2543

Small-subunit processome

4 of 32

1.62

1.64

0.00015

CL:2544

90S preribosome, and Positive regulation of transcription by RNA polymerase I

3 of 17

1.77

1.43

0.0010

CL:1507

RNA polymerase I complex

2 of 5

2.12

1.13

0.0073

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6791226

Major pathway of rRNA processing in the nucleolus and cytosol

7 of 168

1.14

0.00011

MAP-8868773

rRNA processing in the nucleus and cytosol

7 of 171

1.13

0.00011

MAP-72312

rRNA processing

7 of 174

1.12

0.00011

MAP-8953854

Metabolism of RNA

7 of 496

0.67

0.4

0.0354

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030684

Preribosome

6 of 86

1.36

1.45

7.73e-05

GOCC:0032040

Small-subunit processome

4 of 36

1.56

1.25

0.0016

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0698

rRNA processing

5 of 19

1.94

2.79

7.00e-07

KW-0690

Ribosome biogenesis

5 of 20

1.92

2.76

7.00e-07

KW-0539

Nucleus

5 of 240

0.84

0.5

0.0284

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